Prospective Randomized Evaluation of a Collagen/Thrombin and Autologous Platelet Hemostatic Agent During Total Knee Arthroplasty

被引：15

作者：

Bloomfield, Michael R. ^{[1
]}

Klika, Alison K. ^{[1
]}

Molloy, Robert M. ^{[1
]}

Froimson, Mark I. ^{[1
]}

Krebs, Viktor E. ^{[1
]}

Barsoum, Wael K. ^{[1
]}

机构：

[1] Cleveland Clin, Dept Orthopaed Surg A41, Cleveland, OH 44195 USA

来源：

JOURNAL OF ARTHROPLASTY | 2012年 / 27卷 / 05期

关键词：

total knee arthroplasty; blood conservation; Vitagel; platelet-rich plasma; thrombin; BLOOD-LOSS; CLINICAL-USE; DONOR SITES; TRANSFUSION; THROMBIN; HIP; PREVENTION; MANAGEMENT; INFECTION; SURGERY;

D O I：

10.1016/j.arth.2011.09.014

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The purpose of this study was to evaluate the effectiveness of a collagen/thrombin and autologous platelet hemostatic agent in preventing blood loss during primary total knee arthroplasty. This prospective, double-blinded, randomized study was designed to enroll a total of 100 patients. Patients were randomized 1:1 to either the treatment arm (standard hemostasis plus study product) or the control arm (standard hemostasis alone). Transfusion requirements, as determined by a blinded investigator using standardized criteria, were significantly lower in the treatment group (no blood transfusions) compared with the control group (5 transfusions; P = .007). These data support the addition of the study product to prevent blood transfusions after primary total knee arthroplasty.

引用

页码：695 / 702

页数：8

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