A new method for the preparation of olefins from vicinal diols

被引：9

作者：

Adiyaman, M

Jung, YJ

Kim, S

Saha, G

Powell, WS

FitzGerald, GA

Rokach, J

机构：

[1] Florida Inst Technol, Claude Pepper Inst, Melbourne, FL 32901 USA

[2] Florida Inst Technol, Dept Chem, Melbourne, FL 32901 USA

[3] Abant Izzet Baysal Univ, Dept Chem, TR-14280 Golkoy, Bolu, Turkey

[4] Meakins Christie Labs, Montreal, PQ H2X 2P2, Canada

[5] Univ Penn, Ctr Expt Therapeut, Philadelphia, PA 19104 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 21期

基金：

美国国家卫生研究院; 美国国家科学基金会; 英国医学研究理事会;

关键词：

eicosanoid; 1,3-diene; olefin; phenyl lithium; iodohydrin;

D O I：

10.1016/S0040-4039(99)00675-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel method is reported for the transformation of vicinal diols to olefins. This methodology consists in the conversion of iodothiocarbonates such as 16 to olefin 17 with phenyl lithium in excellent yield. Compounds 7 and 12 were prepared by this methodology in order to determine if they would be recognized by the enzymes, 5-lipoxygenase and 15-lipoxygenase, respectively. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：4019 / 4022

页数：4

共 22 条

[1] REGIOCONTROLLED FORMATION OF IODOHYDRINS AND EPOXIDES FROM VIC-DIOLS [J].