Interleukin-6 induced suppression of bovine parathyroid hormone secretion

被引：38

作者：

Carlstedt, E

Ridefelt, P

Lind, L ^{[1
]}

Rastad, J

机构：

[1] Univ Uppsala Hosp, Dept Med, S-75185 Uppsala, Sweden

[2] Univ Uppsala Hosp, Dept Surg, S-75185 Uppsala, Sweden

来源：

BIOSCIENCE REPORTS | 1999年 / 19卷 / 01期

关键词：

parathyroid hormone; proinflammatory cytokines; TNF-alpha; IL-6; hypocalcemia;

D O I：

10.1023/A:1020146023812

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calcium disturbances in the critically ill coincide with elevations of proinflammatory cytokines. The effects of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) on parathyroid hormone (PTH) secretion were investigated. IL-6 and TNF-alpha had no acute effect on PTH secretion in extracellular Ca2+ concentrations of 0.5, 1.25 and 3.0 mM. In contrast to TNF-alpha, cultures for 24 h in the presence of 10 ng/mL of IL-6 showed decreased PTH secretion by 51% and 29% in 0.5 mM and 1.25 mM Ca2+ respectively. Neither IL-6 nor TNF-alpha, affected cytoplasmic Ca2+ of the cells. We conclude that PTH secretion in vitro can be suppressed by IL-6 at clinically relevant concentrations. This suppression may aggravate hypocalcemia of the critically ill and attenuate the conventionally strong stimulation of the PTH release by reduction in serum calcium.

引用

页码：35 / 42

页数：8

共 27 条

[1] Toward a theory regarding the pathogenesis of the systemic inflammatory response syndrome: What we do and do not know about cytokine regulation [J].