Hydrogen Sulfide as an Endogenous Modulator in Mitochondria and Mitochondria Dysfunction

被引：80

作者：

Guo, Wei ^{[1
]}

Kan, Jun-tao ^{[1
]}

Cheng, Ze-yu ^{[1
]}

Chen, Jie-fang ^{[1
]}

Shen, Ya-qi ^{[1
]}

Xu, Jie ^{[1
]}

Wu, Dan ^{[1
]}

Zhu, Yi-zhun ^{[1
,2
,3
]}

机构：

[1] Fudan Univ, Sch Pharm, Dept Pharmacol, Shanghai 201203, Peoples R China

[2] Fudan Univ, Inst Biomed Sci, Shanghai 201203, Peoples R China

[3] Natl Univ Singapore, Dept Pharmacol, Singapore 117597, Singapore

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2012年 / 2012卷

关键词：

OXIDATIVE STRESS; INHIBITION; ISCHEMIA; LUNG; H2S; ANTIOXIDANT; METABOLISM; DISORDERS; MECHANISM; CHANNELS;

D O I：

10.1155/2012/878052

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Hydrogen sulfide (H2S) has historically been considered to be a toxic gas, an environmental and occupational hazard. However, with the discovery of its presence and enzymatic production through precursors of L-cysteine and homocysteine in mammalian tissues, H2S has recently received much interest as a physiological signaling molecule. H2S is a gaseous messenger molecule that has been implicated in various physiological and pathological processes in mammals, including vascular relaxation, angiogenesis, and the function of ion channels, ischemia/reperfusion (I/R), and heart injury. H2S is an endogenous neuromodulator and present studies show that physiological concentrations of H2S enhance NMDA receptor-mediated responses and aid in the induction of hippocampal long-term potentiation. Moreover, in the field of neuronal protection, physiological concentrations of H2S in mitochondria have many favorable effects on cytoprotection.

引用

页数：9

共 63 条

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