Beneficial and detrimental oles of NLRs in carcinogenesis

被引：58

作者：

Janowski, Ann M. ^{[1
,2
]}

Kolb, Ryan ^{[3
]}

Zhang, Weizhou ^{[3
]}

Sutterwala, Fayyaz S. ^{[1
,2
,4
,5
]}

机构：

[1] Univ Iowa, Carver Coll Med, Inflammat Program, Iowa City, IA USA

[2] Univ Iowa, Carver Coll Med, Grad Program Immunol, Iowa City, IA USA

[3] Univ Iowa, Dept Pathol, Carver Coll Med, Iowa City, IA 52242 USA

[4] Univ Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA

[5] Vet Affairs Med Ctr, Iowa City, IA 52242 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2013年 / 4卷

关键词：

inflammasomes; NLR; cancer; interleukin-1; interleukin-18; NF-KAPPA-B; NALP3; INFLAMMASOME; SUPPRESSOR-CELLS; PATTERN-RECOGNITION; CANCER PROGRESSION; COLON INFLAMMATION; BREAST-CANCER; CUTTING EDGE; URIC-ACID; ACTIVATION;

D O I：

10.3389/fimmu.2013.00370

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Inflammation plays a critical role in tumorigenesis and can contribute to oncogenic mutations, tumor promotion, and angiogenesis. Tumor-promoting inflammation is driven by many factors including the presence of the pro-inflammatory cytokines interleukin (IL)-1 beta and 1L-18. One major source of 1L-1 beta and 1L-18 secretion is through the activation of inflammasomes. Inflammasomes are multi-protein complexes that upon activation lead to the processing and secretion of 1L-1 beta and 1L-18 mediated by the cysteine protease caspase-1. Several inflammasomes, including NLRP3, NLRC4, and NLRP6, have been implicated in tumorigenesis. However, inflammasomes play divergent roles in different types of cancer reflecting the complexity of inflammation during tumorigenesis. Understanding the role of inflammasome activation during specific stages of tumorigenesis and also during cancer immunotherapy will help identify novel therapeutic targets that could improve treatment strategies for cancer patients. Here we will discuss recent advances in understanding the mechanism by which NLRs regulate carcinogenesis.

引用

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