WNT signaling in stem cell differentiation and tumor formation

被引：21

作者：

Ouyang, Hong ^{[1
,2
,3
,4
,5
]}

Zhuo, Yehong ^{[6
]}

Zhang, Kang ^{[1
,2
,3
,4
,5
,6
,7
]}

机构：

[1] Sichuan Univ, West China Hosp, Mol Med Res Ctr, Chengdu 610064, Peoples R China

[2] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Dept Ophthalmol, Chengdu 610064, Peoples R China

[3] Univ Calif San Diego, Dept Ophthalmol, San Diego, CA USA

[4] Univ Calif San Diego, Shiley Eye Ctr, San Diego, CA USA

[5] Univ Calif San Diego, Inst Genom Med, San Diego, CA USA

[6] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510060, Guangdong, Peoples R China

[7] Vet Adm Healthcare Syst, San Diego, CA USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2013年 / 123卷 / 04期

关键词：

DEFICIENT MICE; TRANSPLANTATION; TUMORIGENICITY; PRECURSORS; CULTURE;

D O I：

10.1172/JCI69324

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Embryonic stem cells (ESCs) hold great therapeutic promise for the regeneration of functional cell types and clinical applications. However, tumorigenic potential of stem cells in a transplanted host remains a major obstacle. In this issue of the JCI, Cui and colleagues identified TCF7-mediated canonical WNT signaling as a critical determinant of both the tumorigenicity and therapeutic function of ESC-derived retinal progenitor cells (ESC-RPCs). Their findings suggested that addressing key extracellular signaling and related intrinsic factors will be essential for the successful use of ESC-derived progenitor transplantation.

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收藏

页码：1422 / 1424

页数：3

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