Achillea millefolium L. Essential Oil Inhibits LPS-Induced Oxidative Stress and Nitric Oxide Production in RAW 264.7 Macrophages

被引：62

作者：

Chou, Su-Tze ^{[1
]}

Peng, Hsin-Yi ^{[1
]}

Hsu, Jaw-Cherng ^{[2
]}

Lin, Chih-Chien ^{[3
]}

Shih, Ying ^{[3
]}

机构：

[1] Providence Univ, Dept Food & Nutr, Taichung 43301, Taiwan

[2] Hung Kuang Univ, Dept Appl Cosmetol, Taichung 43302, Taiwan

[3] Providence Univ, Dept Cosmet Sci, Taichung 43301, Taiwan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 07期

关键词：

Achillea millefolium L; antioxidant; anti-inflammatory; essential oil; gas chromatography-mass spectrometry (GC-MS); lipopolysaccharides (LPS)-stimulated RAW 264.7 macrophages; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; CHEMICAL-COMPOSITION; ANTIOXIDANT ACTIVITY; LEAF; S.L; SESQUITERPENOIDS; CONSTITUENTS; INVOLVEMENT; FLAVONOIDS;

D O I：

10.3390/ijms140712978

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Achillea millefolium L. is a member of the Asteraceae family and has been used in folk medicine in many countries. In this study, 19 compounds in A. millefolium essential oil (AM-EO) have been identified; the major components are artemisia ketone (14.92%), camphor (11.64%), linalyl acetate (11.51%) and 1,8-cineole (10.15%). AM-EO can suppress the inflammatory responses of lipopolysaccharides (LPS)-stimulated RAW 264.7 macrophages, including decreased levels of cellular nitric oxide (NO) and superoxide anion production, lipid peroxidation and glutathione (GSH) concentration. This antioxidant activity is not a result of increased superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities, but rather occurs as a result of the down-regulation of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and heme oxygenase-1 (HO-1) expression, thus reducing the inflammatory response. Therefore, AM-EO can be utilized in many applications, including the treatment of inflammatory diseases in the future.

引用

页码：12978 / 12993

页数：16

共 48 条

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Artemisia afra Jacq. Ameliorates Oxidative Stress in the Pancreas of Streptozotocin-Induced Diabetic Wistar Rats [J].