Thiazolidine-2,4-diones as multi-targeted scaffold in medicinal chemistry: Potential anticancer agents

被引：142

作者：

Asati, Vivek ^{[1
]}

Mahapatra, Debarshi Kar ^{[1
]}

Bharti, Sanjay K. ^{[1
]}

机构：

[1] Guru Ghasidas Vishwavidyalaya, Inst Pharmaceut Sci, Bilaspur 495009, Chhattisgarh, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2014年 / 87卷

关键词：

Thiazolidine-2,4-dione; ERK; PI3K; Antiproliferative activity; Signaling pathways; Kinases; PROLIFERATOR-ACTIVATED-RECEPTOR; MEK-ERK PATHWAY; PPAR-GAMMA; BIOLOGICAL EVALUATION; GASTRIC-CANCER; CELL-GROWTH; DIFFERENTIAL EXPRESSION; PANCREATIC-CANCER; SIGNALING PATHWAY; HYBRID MOLECULES;

D O I：

10.1016/j.ejmech.2014.10.025

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

A variety of substituents on the thiazolidine-2,4-dione(TZD) nucleus have provided a wide spectrum of biological activities by the using of different mechanism on various target sites. PPAR gamma ligands have recently been demonstrated to affect cell proliferation, differentiation and apoptosis of different cell types. Currently, some of the TZDs are designed for the treatment of human cancers expressing high levels of PPAR gamma because it is assumed that activation of PPAR gamma mediates their anticancer activity. Another site for TZDs is survival signaling pathways under growth factor loops have been implicated in cancer development, progression, and metastasis. The Raf/MEK/ERK, Wnt and PI3K/Akt signalling cascades are the most commonly up-regulated in human cancers. In the present review, various derivatives of thiazolidine-2,4-diones its SAR and different signaling pathways involved to produce anticancer activity been highlighted. (C) 2014 Elsevier Masson SAS. All rights reserved.

引用

页码：814 / 833

页数：20

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