Role of pathways for signal transducers and activators of transcription, and mitogen-activated protein kinase in adipocyte differentiation

被引：20

作者：

Aubert, J ^{[1
]}

Belmonte, N ^{[1
]}

Dani, C ^{[1
]}

机构：

[1] Ctr Biochim, Lab Biol Dev Tissu Adipeux, CNRS, UMR 6543, F-06108 Nice, France

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 1999年 / 56卷 / 5-6期

关键词：

STAT; MAP kinase; adipocyte;

D O I：

10.1007/s000180050450

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Members of the signal transducer and activator of transcription (STAT) family and the mitogen-activated protein kinase (MAPK) cascade play a major role in the regulation of cell growth and differentiation. This review concentrates on the role played by these pathways in the development of adipose cells. STATs are activated by both positive and negative modulators of adipocyte differentiation leading to the hypothesis that the STAT pathway may function in adipogenesis. The role of the p42/p44 MAPK pathway in adipocyte differentiation has recently been the subject of contradictory reports. Several molecular mechanisms are proposed to explain the opposing effects of MAPK activation in the programme of adipose cell differentiation.

引用

页码：538 / 542

页数：5

共 46 条

[1] CELLULAR AND MOLECULAR ASPECTS OF ADIPOSE-TISSUE DEVELOPMENT [J].

AILHAUD, G ;

GRIMALDI, P ;

NEGREL, R .

ANNUAL REVIEW OF NUTRITION, 1992, 12 :207-233

[2]

AMRI EZ, 1994, J LIPID RES, V35, P930

[3] SIMULTANEOUS ACTIVATION OF P90(RSK) AND P70(S6K) S6-KINASES BY GROWTH-HORMONE IN 3T3-F442A PREADIPOCYTES [J].

ANDERSON, NG .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 193 (01) :284-290

[4] Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway [J].

Bonni, A ;

Sun, Y ;

NadalVicens, M ;

Bhatt, A ;

Frank, DA ;

Rozovsky, I ;

Stahl, N ;

Yancopoulos, GD ;

Greenberg, ME .

SCIENCE, 1997, 278 (5337) :477-483

[5]

CARTER SC, 1996, ANNU REV PHYSIOL, V58, P187

[6]

Carter-Su Christin, 1996, Endocrine Journal, V43, pS65, DOI 10.1507/endocrj.43.Suppl_S65

[7] ACTIVATION OF MAP KINASE KINASE IS NECESSARY AND SUFFICIENT FOR PC12 DIFFERENTIATION AND FOR TRANSFORMATION OF NIH 3T3 CELLS [J].

COWLEY, S ;

PATERSON, H ;

KEMP, P ;

MARSHALL, CJ .

CELL, 1994, 77 (06) :841-852

[8] Mitogen-activated protein kinase activation is not necessary for, but antagonizes, 3T3-L1 adipocytic differentiation [J].

deMora, JF ;

Porras, A ;

Ahn, N ;

Santos, E .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (10) :6068-6075

[9] PC12 CELLS OVEREXPRESSING THE INSULIN-RECEPTOR UNDERGO INSULIN-DEPENDENT NEURONAL DIFFERENTIATION [J].

DIKIC, I ;

SCHLESSINGER, J ;

LAX, I .

CURRENT BIOLOGY, 1994, 4 (08) :702-708

[10]

DOGLIO A, 1986, BIOCHEM J, V238, P123, DOI 10.1042/bj2380123

← 1 2 3 4 5 →