GalaxyWEB server for protein structure prediction and refinement

被引：662

作者：

Ko, Junsu ^{[1
]}

Park, Hahnbeom ^{[1
]}

Heo, Lim ^{[1
]}

Seok, Chaok ^{[1
]}

机构：

[1] Seoul Natl Univ, Dept Chem, Seoul 151747, South Korea

来源：

NUCLEIC ACIDS RESEARCH | 2012年 / 40卷 / W1期

基金：

新加坡国家研究基金会;

关键词：

LOOP;

D O I：

10.1093/nar/gks493

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Three-dimensional protein structures provide invaluable information for understanding and regulating biological functions of proteins. The GalaxyWEB server predicts protein structure from sequence by template-based modeling and refines loop or terminus regions by ab initio modeling. This web server is based on the method tested in CASP9 (9th Critical Assessment of techniques for protein Structure Prediction) as 'Seok-server', which was assessed to be among top performing template-based modeling servers. The method generates reliable core structures from multiple templates and re-builds unreliable loops or termini by using an optimization-based refinement method. In addition to structure prediction, a user can also submit a refinement only job by providing a starting model structure and locations of loops or termini to refine. The web server can be freely accessed at http://galaxy.seoklab.org/.

引用

收藏

页码：W294 / W297

页数：4

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