Postmenopausal acceleration of age-related mortality increase

被引:37
作者
Horiuchi, S
机构
[1] Laboratory of Populations, Rockefeller University, New York City
[2] Rockefeller University, Box 20, New York, NY 10021-6399
来源
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 1997年 / 52卷 / 01期
关键词
D O I
10.1093/gerona/52A.1.B78
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 [法学]; 0303 [社会学]; 100203 [老年医学];
摘要
The force of natural selection to eliminate deleterious genes in attenuated with advancing age, allowing senescence to evolve. This suggests that a distinctly marked end of the reproduction period is likely to be followed by an acceleration of senescence. It is thus expected that menopause should trigger an acceleration of age-related mortality increase in human females. Such an abrupt initiation of mortality acceleration is not predicted for human mules at the same ages, whose fecundity declines more gradually. Life table aging rate patterns for selected industrialized countries generally support this hypothesis. A cause-of-death decomposition analysis indicates that the sex differential in mortality acceleration is mainly due to cardiovascular diseases, which is consistent with the prevalent view that postmenopausal changes in the sex hormone status may affect lipoprotein metabolism, and in turn, raise the risk of arteriosclerosis.
引用
收藏
页码:B78 / B92
页数:15
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