Memory alterations during acute high-intensity vagus nerve stimulation

被引：63

作者：

Helmstaedter, C ^{[1
]}

Hoppe, C ^{[1
]}

Elger, CE ^{[1
]}

机构：

[1] Univ Bonn, Dept Epileptol, D-53105 Bonn, Germany

来源：

EPILEPSY RESEARCH | 2001年 / 47卷 / 1-2期

关键词：

epilepsy; vagus nerve stimulation; memory; attention; lateralized effect;

D O I：

10.1016/S0920-1211(01)00291-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Left cervical vagus nerve stimulation (VNS) is an accepted add-on treatment for pharmacoresistant epilepsy. However. it also allows the investigation of the effects of peripheral nerve stimulation on central nervous functions. The impact of 4.5 min high intensity VNS ( > 1 mA) on material-specific memory and decision times was evaluated in an experimental 'box car' design in 11 patients with pharmacoresistant epilepsy. Results indicate reversible deterioration of figural but not verbal memory and a trend of accelerated decision times during VNS. Thus, further support of cognitive effects of VNS is provided. There are indications of a major projection of VNS to activating brain structures of and the right hemisphere. Significant cognitive side effects in clinical application are unlikely because of the reversibility of the effect and differences between experimental and therapeutic stimulation conditions. However., since the effectors and the direction of the cognitive effects of VNS seem to depend strongly on stimulation conditions, we recommend future experimental research covering a larger range of stimulation conditions. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：37 / 42

页数：6

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