A new regio- and stereoselective intermolecular Friedel-Crafts alkylation of phenolic substrates with aryl epoxides

被引：22

作者：

Bertolini, F ^{[1
]}

Crotti, P ^{[1
]}

Macchia, F ^{[1
]}

Pineschi, M ^{[1
]}

机构：

[1] Univ Pisa, Dipartimento Chim Bioorgan & Biofarm, I-56126 Pisa, Italy

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 01期

关键词：

Friedel-Crafts alkylation; epoxides; regioselectivity; stereoselectivity;

D O I：

10.1016/j.tetlet.2005.10.138

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A conceptually new regioselective and highly syn-stereoselective intermolecular Friedel-Crafts-type O-alkylation of phenols with aryl epoxides by the use of appropriately substituted aryl borates is reported. The carbon-carbon bond formation occurs in neutral and mild conditions without the need for external Lewis acids or transition metal catalysts. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：61 / 64

页数：4

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