Comparison of short-term diet and exercise on insulin action in individuals with abnormal glucose tolerance

被引:54
作者
Arciero, PJ [1 ]
Vukovich, MD [1 ]
Holloszy, JO [1 ]
Racette, SB [1 ]
Kohrt, WM [1 ]
机构
[1] Washington Univ, Sch Med, Dept Internal Med, Div Geriatr & Gerontol, St Louis, MO 63110 USA
关键词
hyperglycemic clamp; low-calorie diet; exercise training; glucose disposal;
D O I
10.1152/jappl.1999.86.6.1930
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The effects of a 10-day low-calorie diet (LCD; n = 8) or exercise training (ET; n = 8) on insulin secretion and action were compared in obese men (n = 9) and women (n = 7), aged 53 +/- 1 yr, with abnormal glucose tolerance by using a hyperglycemic clamp with superimposed arginine infusion and a high-fat drink. Body mass (LCD, 115 +/- 5 vs. 110 +/- 5 kg; ET, 111 +/- 7 vs. 109 +/- 7 kg; P < 0.01) and fasting plasma glucose (LCD, 115 +/- 10 vs. 99 +/- 4 mg/dl; ET, 112 +/- 4 vs. 101 +/- 5 mg/dl, P < 0.01) and insulin (LCD, 23.9 +/- 5.6 vs. 15.2 +/- 3.9 mu U/ml; ET, 17.6 +/- 1.9 vs. 13.9 +/- 2.4 mu U/ml; P < 0.05) decreased in both groups. There was a 40% reduction in plasma insulin during hyperglycemia (0-45 min) after LCD (peak: 118 +/- 18 vs. 71 +/- 14 mu U/ml; P < 0.05) and ET (69 +/- 14 vs. 41 +/- 7 mu U/ml; P < 0.05) and trends for reductions during arginine infusion and a high-fat drink. The 56% increase in glucose uptake after ET (4.95 +/- 0.90 vs. 7.74 +/- 0.82 mg.min(-1).kg fat-free mass(-1); P < 0.01) was significantly (P < 0.01) greater than the 19% increase (5.72 +/- 1.12 vs. 6.80 +/- 0.94 mg.min(-1).kg fat-free mass(-1); P = not significant) that occurred after LCD. The marked increase in glucose disposal after ET, despite lower insulin levels, suggests that short-term exercise is more effective than diet in enhancing insulin action in individuals with abnormal glucose tolerance.
引用
收藏
页码:1930 / 1935
页数:6
相关论文
共 41 条
[1]   A PRACTICAL EQUATION TO PREDICT RESTING METABOLIC-RATE IN OLDER MEN [J].
ARCIERO, PJ ;
GORAN, MI ;
GARDNER, AW ;
ADES, PA ;
TYZBIR, RS ;
POEHLMAN, ET .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1993, 42 (08) :950-957
[2]   A PRACTICAL EQUATION TO PREDICT RESTING METABOLIC-RATE IN OLDER FEMALES [J].
ARCIERO, PJ ;
GORAN, MI ;
GARDNER, AM ;
ADES, PA ;
TYZBIR, RS ;
POEHLMAN, ET .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1993, 41 (04) :389-395
[3]   DIET AND EXERCISE IN THE TREATMENT OF NIDDM - THE NEED FOR EARLY EMPHASIS [J].
BARNARD, RJ ;
JUNG, T ;
INKELES, SB .
DIABETES CARE, 1994, 17 (12) :1469-1472
[4]  
BJORNTORP P, 1988, DIABETES METAB REV, V4, P615, DOI 10.1002/dmr.5610040607
[5]   EFFECTS OF PHYSICAL-TRAINING AND DIET THERAPY ON CARBOHYDRATE-METABOLISM IN PATIENTS WITH GLUCOSE-INTOLERANCE AND NON-INSULIN-DEPENDENT DIABETES-MELLITUS [J].
BOGARDUS, C ;
RAVUSSIN, E ;
ROBBINS, DC ;
WOLFE, RR ;
HORTON, ES ;
SIMS, EAH .
DIABETES, 1984, 33 (04) :311-318
[6]   EFFECT OF EXERCISE ON GLUCOSE DISPOSAL - RESPONSE TO A MAXIMAL INSULIN STIMULUS [J].
BOUREY, RE ;
COGGAN, AR ;
KOHRT, WM ;
KIRWAN, JP ;
KING, DS ;
HOLLOSZY, JO .
JOURNAL OF APPLIED PHYSIOLOGY, 1990, 69 (05) :1689-1694
[7]   EFFECTS OF EXERCISE INTENSITY ON INSULIN SENSITIVITY IN WOMEN WITH NON-INSULIN-DEPENDENT DIABETES-MELLITUS [J].
BRAUN, B ;
ZIMMERMANN, MB ;
KRETCHMER, N .
JOURNAL OF APPLIED PHYSIOLOGY, 1995, 78 (01) :300-306
[8]   DENSITOMETRIC ANALYSIS OF BODY COMPOSITION REVISION OF SOME QUANTIATIVE ASSUMPTIONS [J].
BROZEK, J ;
ANDERSON, JT ;
KEYS, A ;
GRANDE, F .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1963, 110 (01) :113-&
[9]   PROLONGED INCREASE IN INSULIN-STIMULATED GLUCOSE-TRANSPORT IN MUSCLE AFTER EXERCISE [J].
CARTEE, GD ;
YOUNG, DA ;
SLEEPER, MD ;
ZIERATH, J ;
WALLBERGHENRIKSSON, H ;
HOLLOSZY, JO .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (04) :E494-E499
[10]   PATHOGENESIS OF NIDDM - A BALANCED OVERVIEW [J].
DEFRONZO, RA ;
BONADONNA, RC ;
FERRANNINI, E .
DIABETES CARE, 1992, 15 (03) :318-368