Human Stem Cell-like Memory T Cells Are Maintained in a State of Dynamic Flux

被引：66

作者：

Ahmed, Raya ^{[1
]}

Roger, Laureline ^{[2
]}

del Amo, Pedro Costa ^{[3
]}

Miners, Kelly L. ^{[2
]}

Jones, Rhiannon E. ^{[4
]}

Boelen, Lies ^{[3
]}

Fali, Tinhinane ^{[5
,6
]}

Elemans, Marjet ^{[3
]}

Zhang, Yan ^{[1
]}

Appay, Victor ^{[5
,6
]}

Baird, Duncan M. ^{[4
]}

Asquith, Becca ^{[3
]}

Price, David A. ^{[2
,7
]}

Macallan, Derek C. ^{[1
,8
]}

Ladell, Kristin ^{[2
]}

机构：

[1] St Georges Univ London, Inst Infect & Immun, London SW17 0RE, England

[2] Cardiff Univ, Sch Med, Div Infect & Immun, Heath Pk, Cardiff CF14 4XN, S Glam, Wales

[3] St Marys Hosp, Imperial Coll London, Dept Med, London W2 1PG, England

[4] Cardiff Univ, Sch Med, Div Canc & Genet, Heath Pk, Cardiff CF14 4XN, S Glam, Wales

[5] UPMC Univ Paris 06, Sorbonne Univ, CIMI Paris, F-75013 Paris, France

[6] CIMI Paris, INSERM U1135, F-75013 Paris, France

[7] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

[8] St Georges Univ Hosp Natl Hlth Serv Fdn Trust, Blackshaw Rd, London SW17 0QT, England

来源：

CELL REPORTS | 2016年 / 17卷 / 11期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

HIV DISEASE; PROLIFERATION; DIVISION; DIVERSIFICATION; DIFFERENTIATION; INFECTION; TURNOVER; WATER; DNA;

D O I：

10.1016/j.celrep.2016.11.037

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Adaptive immunity requires the generation of memory T cells from naive precursors selected in the thymus. The key intermediaries in this process are stem cell-like memory T (T-SCM) cells, multipotent progenitors that can both self-renew and replenish more differentiated subsets of memory T cells. In theory, antigen specificity within the T-SCM pool may be imprinted statically as a function of largely dormant cells and/or retained dynamically by more transitory subpopulations. To explore the origins of immunological memory, we measured the turnover of T-SCM cells in vivo using stable isotope labeling with heavy water. The data indicate that T-SCM cells in both young and elderly subjects are maintained by ongoing proliferation. In line with this finding, T-SCM cells displayed limited telomere length erosion coupled with high expression levels of active telomerase and Ki67. Collectively, these observations show that T-SCM cells exist in a state of perpetual flux throughout the human lifespan.

引用

页码：2811 / 2818

页数：8

共 34 条

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