Assessment of neurotoxicity following repeated cremophor/ethanol injections in rats

被引：27

作者：

Authier, Nicolas ^{[1
]}

Gillet, Jean-Pierre ^{[4
]}

Fialip, Joseph ^{[2
]}

Eschalier, Alain ^{[3
]}

Coudore, Francois ^{[1
]}

机构：

[1] Univ Auvergne, INSERM EMI 9904, Fac Pharm, Lab Toxicol, F-63001 Clermont Ferrand, France

[2] Univ Auvergne, INSERM EMI 9904, Fac Pharm, Lab Pharmacol, F-63001 Clermont Ferrand, France

[3] Univ Auvergne, INSERM EMI 9904, Fac Pharm, Equipe NeuroPsychoPharmacol,Lab Pharmacol Med, F-63001 Clermont Ferrand, France

[4] Ctr Rech, F-63200 Riom, France

来源：

NEUROTOXICITY RESEARCH | 2001年 / 3卷 / 03期

关键词：

neurotoxicity; nociception; hyperalgesia; allodynia;

D O I：

10.1007/BF03033269

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

As the mixture cremophor/ethanol is known to have side-effects affecting the peripheral nervous system, we have assessed its behavioural and morphological neurotoxicity after repeated intraperitoneal injections in male Sprague Dawley rats. Clinical status of the animals was good throughout the experiment and no motor deficits were observed. Nevertheless, sensory testing demonstrated an hyperalgesia and an allodynia to mechanical stimuli, associated to peripheral axon degeneration.

引用

页码：301 / 306

页数：6

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