The new role of calcimimetics as vasculotropic agents

被引：8

作者：

Al-Aly, Ziyad ^{[1
,2
]}

机构：

[1] St Louis Vet Affairs Med Ctr, Div Nephrol, St Louis, MO 63106 USA

[2] St Louis Vet Affairs Clin Res & Epidemiol Ctr, St Louis, MO USA

来源：

KIDNEY INTERNATIONAL | 2009年 / 75卷 / 01期

关键词：

CALCIUM-SENSING RECEPTOR; SECONDARY HYPERPARATHYROIDISM; CINACALCET HCL; UREMIC RATS; PROGRESSION; CALCITRIOL;

D O I：

10.1038/ki.2008.563

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

100201 [内科学]; 100221 [泌尿外科学];

摘要：

The discovery of the calcium-sensing receptor (CaSR) and the development of calcimimetics have provided new insights into calcium homeostasis and new therapeutic opportunities for parathyroid-related disorders. However, the CaSR is also implicated in various other cellular processes, and the translational applications of calcimimetics may not be exclusively calcium-centric. Koleganova et al. describe a novel role for calcimimetics as vasculotropes, which provides the impetus for further studies to characterize their effects on vascular biology.

引用

收藏

页码：9 / 12

页数：5

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