Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions

被引：128

作者：

Christophersen, Asbjorn ^{[1
,2
,3
,4
]}

Lund, Eivind G. ^{[1
,2
,3
]}

Snir, Omri ^{[1
,2
,3
]}

Sola, Elsa ^{[4
,5
]}

Kanduri, Chakravarthi ^{[1
,6
]}

Dahal-Koirala, Shiva ^{[1
,2
,3
]}

Zuhlke, Stephanie ^{[1
,2
,3
]}

Molberg, Oyvind ^{[2
,7
]}

Utz, Paul J. ^{[4
]}

Rohani-Pichavant, Mina ^{[4
]}

Simard, Julia F. ^{[8
]}

Dekker, Cornelia L. ^{[9
]}

Lundin, Knut E. A. ^{[1
,2
,10
]}

Sollid, Ludvig M. ^{[1
,2
,3
,11
]}

Davis, Mark M. ^{[4
,12
,13
]}

机构：

[1] Univ Oslo, KG Jebsen Coeliac Dis Res Ctr, Oslo, Norway

[2] Univ Oslo, Inst Clin Med, Oslo, Norway

[3] Univ Oslo, Dept Immunol, Oslo, Norway

[4] Stanford Univ, Sch Med, Inst Immun Transplantat & Infect, Stanford, CA 94305 USA

[5] Univ Barcelona, Hosp Clin Barcelona, Liver Unit, IDIBAPS, Barcelona, Spain

[6] Univ Oslo, Dept Informat, Oslo, Norway

[7] Oslo Univ Hosp, Dept Rheumatol Dermatol & Infect Dis, Oslo, Norway

[8] Stanford Sch Med, Epidemiol Hlth Res & Policy, Stanford, CA 94305 USA

[9] Stanford Univ, Dept Pediat, Sch Med, Stanford, CA 94305 USA

[10] Oslo Univ Hosp, Dept Gastroenterol, Oslo, Norway

[11] Oslo Univ Hosp, Dept Immunol, Oslo, Norway

[12] Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA

[13] Stanford Univ, Howard Hughes Med Inst, Sch Med, Stanford, CA 94305 USA

来源：

NATURE MEDICINE | 2019年 / 25卷 / 05期

基金：

美国国家卫生研究院;

关键词：

PERIPHERAL-BLOOD; AMERICAN-COLLEGE; TRANSGLUTAMINASE; CLASSIFICATION; AUTOANTIBODIES; EXPRESSION; CYTOMETRY; CRITERIA; TIME;

D O I：

10.1038/s41591-019-0403-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Combining HLA-DQ-gluten tetramers with mass cytometry and RNA sequencing analysis, we find that gluten-specific CD4(+) T cells in the blood and intestines of patients with celiac disease display a surprisingly rare phenotype. Cells with this phenotype are also elevated in patients with systemic sclerosis and systemic lupus erythematosus, suggesting a way to characterize CD4(+) T cells specific for disease-driving antigens in multiple autoimmune conditions.

引用

页码：734 / +

页数：16

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