Anthrax, MEK and Cancer

被引：25

作者：

Bodart, J. F. ^{[1
,2
]}

Chopra, A. ^{[1
]}

Liang, X. ^{[1
]}

Duesbery, N. ^{[1
]}

机构：

[1] Van Andel Res Inst, Lab Dev Cell Biol, Grand Rapids, MI 49503 USA

[2] Univ Sci & Technol Lille, Lab Biol Dev, UPRES EA 1033, SN3, F-59655 Villeneuve Dascq, France

来源：

CELL CYCLE | 2002年 / 1卷 / 01期

关键词：

Anthrax; MEK; MAPK; Cancer;

D O I：

10.4161/cc.1.1.95

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The MEK family of protein kinases plays key roles in regulating cellular responses to mitogens as well as environmental stress. Inappropriate activation of these kinases contributes to tumorigenesis. In contrast, anthrax lethal factor, the principal virulence factor of anthrax toxin, has been demonstrated to selectively inactivate MEKs. In this article we will discuss recent advances in our understanding of molecular aspects of the pathogenesis of anthrax, emphasizing the potential role of MEK signalling in this disease, and outline novel strategies to use anthrax lethal toxin in the treatment of cancer.

引用

页码：10 / 15

页数：6

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