Antimalarial drug resistance

被引：242

作者：

White, NJ

机构：

[1] Mahidol Univ, Fac Trop Med, Bangkok 10400, Thailand

[2] Churchill Hosp, Ctr Vaccinol & Trop Med, Oxford OX3 7LJ, England

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 113卷 / 08期

关键词：

D O I：

10.1172/JCI200421682

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Malaria, the most prevalent and most pernicious parasitic disease of humans, is estimated to kill between one and two million people, mainly children, each year. Resistance has emerged to all classes of antimalarial drugs except the artemisinins and is responsible for a recent increase in malaria-related mortality, particularly in Africa. The de novo emergence of resistance can be prevented by the use of antimalarial drug combinations. Artemisinin-derivative combinations are particularly effective, since they act rapidly and are well tolerated and highly effective. Widespread use of these drugs could roll back malaria.

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页码：1084 / 1092

页数：9

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