Selective induction of apoptosis by ar-turmerone isolated from turmeric (Curcuma longa L) in two human leukemia cell lines, but not in human stomach cancer cell line

被引：21

作者：

Aratanechemuge, Y

Komiya, T ^{[1
]}

Moteki, H

Katsuzaki, H

Imai, K

Hibasami, H

机构：

[1] Mie Univ, Fac Resources, Tsu, Mie 5140001, Japan

[2] Mie Univ, Fac Med, Tsu, Mie 5140001, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2002年 / 9卷 / 05期

关键词：

ar-turmerone; growth inhibition; apoptosis; DNA fragmentation; human leukemia cell lines;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

We have investigated the effects of ar-turmerone isolated from turmeric (Curcuma longa L) on DNA of human leukemia cell lines, Molt 413, HL-60 and stomach cancer KATO III cells. It was found that selective induction of apoptosis by ar-turmerone was observed in human leukemia Molt 4B and HL-60 cells, but not in human stomach cancer KATO III cells. Morphological changes showing apoptotic bodies were observed in the human HL-60 and Molt 4B cells treated with ar-turmerone. The fragmentation of DNA by arturmerone to oligonucleosomal-sized fragments that is a characteristic of apoptosis was observed to be concentration and time-dependent in Molt 4B and HL-60 cells, but not in KATO III cells. The data of the present study show that the suppression by ar-turmerone of growth of these leukemia cell lines results from the induction of apoptosis by this compound.

引用

页码：481 / 484

页数：4

共 16 条

[1]

CHEMOTHERAPY-INDUCED APOPTOSIS IN EPITHELIAL OVARIAN CANCERS [J].