Complex genetics of drug resistance in Mycobacterium tuberculosis

被引：20

作者：

Warner, Digby F. ^{[1
]}

Mizrahi, Valerie ^{[1
]}

机构：

[1] Univ Cape Town, NHLS, MRC, Mol Mycobacteriol Res Unit, ZA-7700 Rondebosch, South Africa

来源：

NATURE GENETICS | 2013年 / 45卷 / 10期

关键词：

D O I：

10.1038/ng.2769

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Three new studies have used whole-genome sequencing of M. tuberculosis to demonstrate unexpected complexity in the modern evolution of drug-resistant tuberculosis, and a fourth study suggests a close evolutionary relationship between the pathogen and its human host over a period of 70,000 years. Collectively, the observations in these studies suggest that future strategies to tackle drug-resistant tuberculosis must integrate host genetics with detailed strain epidemiology.

引用

页码：1107 / 1108

页数：3

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