Photochemical regulation of DNA-binding specificity of MyoD

被引：63

作者：

Guerrero, L

Smart, OS

Weston, CJ

Burns, DC

Woolley, GA

Allemann, RK

机构：

[1] Univ Cardiff Wales, Sch Chem, Cardiff CF10 3AT, Wales

[2] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England

[3] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 47期

关键词：

azo compounds; DNA; fluorescence anisotropy; photosomerization; transcription factors;

D O I：

10.1002/anie.200502666

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Lighting up: The conformation of the DNA-binding domain of the basic helix-loop-helix protein MyoD can be controlled through an azobenzene cross-linker in response to light flashes. The DNA binding specificity of alkylated MyoD can be modulated through the isomerization of the cross-linker to the cis conformer, which leads to significantly enhanced sequence selectivity. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：7778 / 7782

页数：5

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