Cell culture models of transmissible spongiform encephalopathies

被引：23

作者：

Béranger, F ^{[1
]}

Mangé, A ^{[1
]}

Solassol, J ^{[1
]}

Lehmann, S ^{[1
]}

机构：

[1] Inst Genet Humaine, CNRS, UPR 1142, F-34396 Montpellier 5, France

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 289卷 / 02期

关键词：

prion; neurodegeneration; cell culture;

D O I：

10.1006/bbrc.2001.5941

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this review, we describe the generation and use of cell culture models of transmissible spongiform encephalopathies, also known as prion diseases. These models include chronically prion-infected cell lines, as well as cultures expressing variable amounts of wild-type, mutated, or chimeric prion proteins. These cell lines have been widely used to investigate the biology of both the normal and the pathological isoform of the prion protein. They have also contributed to the, comprehension of the pathogenic processes occurring in transmissible spongiform encephalopathies and in the development of new therapeutic approaches of these diseases. (C) 2001 Elsevier Science.

引用

页码：311 / 316

页数：6

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