Studies on the synthesis of 16 alpha-[F-18]fluoroestradiol

被引：31

作者：

Romer, J ^{[1
]}

Steinbach, J ^{[1
]}

Kasch, H ^{[1
]}

机构：

[1] HANS KNOLL INST JENA,D-07745 JENA,GERMANY

来源：

APPLIED RADIATION AND ISOTOPES | 1996年 / 47卷 / 04期

关键词：

D O I：

10.1016/0969-8043(95)00330-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

For preparing 16 alpha-[F-18]fluoroestradiol, a new one-pot procedure reported in the literature was elaborated in detail. The experimental conditions for synthesizing the required precursor and for converting it into 16 alpha-fluoroestradiol or 16 alpha-[F-18]fluoroestradiol are given. The synthesis consists of the fluoridation reaction and hydrolysis reactions. For rapid hydrolysis of the fluorosteroid formed in the fluoridation reaction two methods are presented. The synthesis time does not exceed 1 h. Pure 16 alpha-[F-18]fluoroestradiol can be obtained in a 70% overall radiochemical yield.

引用

页码：395 / 399

页数：5

共 8 条

[1] REINTERPRETATION OF BETA-SUBSTITUENT, GAMMA-SUBSTITUENT, AND DELTA-SUBSTITUENT EFFECTS ON C-13 CHEMICAL-SHIFTS [J].