Prognostic significance of the detection of human papilloma virus L1 protein in smears of mild to moderate cervical intraepithelial lesions

被引:60
作者
Rauber, D. [1 ]
Mehlhorn, G. [1 ]
Fasching, P. A. [1 ]
Beckmann, M. W. [1 ]
Ackermann, S. [1 ,2 ]
机构
[1] Erlangen Univ Hosp, Dept Obstet & Gynecol, Erlangen, Germany
[2] Darmstadt Gen Hosp, Dept Obstet & Gynecol, Darmstadt, Germany
关键词
Antibodies; Human papillomavirus; Cervical dysplasia; Prognosis; Immunohistochemistry; Capsids;
D O I
10.1016/j.ejogrb.2008.05.003
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To investigate whether it is possible to use detection of the human papillomavirus (HPV) L1 capsid protein to predict the course of mild or moderate cervical intraepithelial neoplasia (CIN). Study design: Pap smears from 279 women in whom CIN 1 and CIN 2 had been diagnosed by cytology and histology, who were known to have a high-risk HPV status and had a median follow-up of 25 months, were immunohistochemically stained for the HPV L1 protein. The staining results were correlated with the clinical course of the disease. Results: HPV L1-positive patients showed regression in 49.1% of cases, stable disease in 41.5%, and progressive disease in 9.4%, whereas HPV L1-negative women had progression in 25.9% of cases (regression 33.3%, stable disease 40.7%; p = 0.001). The effect was clearest in the group under 30 years of age. HPV L1-negative patients experienced progression significantly more often than women with a positive HPV L1 test (odds ratio 3.391). Conclusions: HPV L1-positivity was found to have prognostic significance in relation to disease progression in women with CIN 1 and CIN 2 and particularly in those less than 30 years of age. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:258 / 262
页数:5
相关论文
共 35 条
  • [1] Baak JPA, 2005, METH MOLEC MED, V119, P85
  • [2] Baak JPA, 2005, CELL ONCOL, V27, P357
  • [3] Baak JPA, 2005, CELL ONCOL, V27, P277
  • [4] Signal-amplified colorimetric in situ hybridization for assessment of human papillomavirus infection in cervical lesions
    Birner, P
    Bachtiary, B
    Dreier, B
    Schindl, M
    Joura, EA
    Breitenecker, G
    Oberhuber, G
    [J]. MODERN PATHOLOGY, 2001, 14 (07) : 702 - 709
  • [5] Ciavattini A, 1999, ANTICANCER RES, V19, P5463
  • [6] Human papillomavirus testing in primary screening for the detection of high-grade cervical lesions: a study of 7932 women
    Clavel, C
    Masure, L
    Bory, JP
    Putaud, I
    Mangeonjean, C
    Lorenzato, M
    Nazeyrollas, P
    Gabriel, R
    Quereux, C
    Birembaut, P
    [J]. BRITISH JOURNAL OF CANCER, 2001, 84 (12) : 1616 - 1623
  • [7] Dellas A, 1998, ANTICANCER RES, V18, P3991
  • [8] New markers for cervical dysplasia to visualise the genomic chaos created by aberrant oncogenic papillomavirus infections
    Doeberitz, MV
    [J]. EUROPEAN JOURNAL OF CANCER, 2002, 38 (17) : 2229 - 2242
  • [9] New molecular tools for efficient screening of cervical cancer
    Doeberitz, MV
    [J]. DISEASE MARKERS, 2001, 17 (03) : 123 - 128
  • [10] Molecular biology of human papillomavirus infection and cervical cancer
    Doorbar, John
    [J]. CLINICAL SCIENCE, 2006, 110 (05) : 525 - 541