Reflux symptom relief with omeprazole in patients without unequivocal oesophagitis

被引:116
作者
Bate, CM
Griffin, SM
Keeling, PWN
Axon, ATR
Dronfield, MW
Chapman, RWG
ODonoghue, D
Calam, J
Crowe, J
Mountford, RA
Watts, DA
Taylor, MD
Richardson, PDI
机构
[1] NEWCASTLE GEN HOSP,NEWCASTLE TYNE NE4 6BE,TYNE & WEAR,ENGLAND
[2] ST JAMES HOSP,DUBLIN 8,IRELAND
[3] LEEDS GEN INFIRM,LEEDS,W YORKSHIRE,ENGLAND
[4] PETERBOROUGH DIST GEN HOSP,PETERBOROUGH PE3 6DA,ENGLAND
[5] JOHN RADCLIFFE HOSP,OXFORD OX3 9DU,ENGLAND
[6] ST VINCENTS HOSP,DUBLIN 4,IRELAND
[7] HAMMERSMITH HOSP,LONDON,ENGLAND
[8] MATER MISERICORDIAE HOSP,DUBLIN 7,IRELAND
[9] BRISTOL ROYAL INFIRM & GEN HOSP,BRISTOL,AVON,ENGLAND
[10] ASTRA PHARMACEUT LTD,DEPT CLIN RES,KINGS LANGLEY,ENGLAND
关键词
D O I
10.1046/j.1365-2036.1996.44186000.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: As many as 50 % of patients with reflux symptoms have no endoscopic evidence of oesophagitis. This multicentre study was designed to assess symptom relief after omeprazole 20 mg once daily in patients with symptoms typical of gastro-oesophageal reflux disease but without endoscopic evidence of oesophagitis. Methods: Patients (n = 209) were randomized in a double-blind study to receive either omeprazole 20 mg once daily (n = 98) or placebo (n = 111) for 4 weeks. Symptoms were assessed at clinic visits and using daily diary cards, with patient-completed questionnaires providing additional data on symptoms and on psychological disturbance. Results: On completion, symptom relief favoured omeprazole: 57% of patients on omeprazole were free of heartburn (vs. 19% on placebo), 75% were free of regurgitation (47%) and 43% were completely asymptomatic (14%), each with P < 0.0001. Fewer patients in the omeprazole group required alginate/antacid relief medication (P < 0.05). Symptom relief (time to first heartburn-free day) was more rapid with omeprazole (2 vs. 5 days on placebo; P < 0.01). A greater reduction in anxiety occurred in the omeprazole group (P < 0.05). Conclusion: Omeprazole 20 mg once daily is effective in providing relief of the symptoms typical of gastrooesophageal reflux disease in patients with essentially normal oesophageal mucosa.
引用
收藏
页码:547 / 555
页数:9
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