Synthesis and cytotoxic activity of new acridine-thiazolidine derivatives

被引：75

作者：

Barros, Francisco W. A. ^{[2
]}

Silva, Teresinha Goncalves ^{[1
]}

da Rocha Pitta, Marina Galdino ^{[1
]}

Bezerra, Daniel P. ^{[3
]}

Costa-Lotufo, Leticia V. ^{[2
]}

de Moraes, Manoel Odorico ^{[2
]}

Pessoa, Claudia ^{[2
]}

de Moura, Maria Aline F. B. ^{[4
]}

de Abreu, Fabiane C. ^{[4
]}

Alves de Lima, Maria do Carmo ^{[1
]}

Galdino, Suely Lins ^{[1
]}

Pitta, Ivan da Rocha ^{[1
]}

Goulart, Marilia O. F. ^{[4
]}

机构：

[1] Univ Fed Pernambuco, Lab Planejamento & Sintese Farmacos LPSF, Grp Pesquisa Inovacao Terapeut GPIT, BR-50670901 Recife, PE, Brazil

[2] Univ Fed Ceara, Dept Fisiol & Farmacol, Fac Med, Fortaleza, Ceara, Brazil

[3] Univ Fed Sergipe, Dept Fisiol, Ctr Ciencias Biol & Saude, Sao Cristovao, Sergipe, Brazil

[4] Univ Fed Alagoas, Inst Quim & Biotecnol, Maceio, Alagoas, Brazil

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2012年 / 20卷 / 11期

关键词：

Acridine; Thiazolidines; Cytotoxicity; DNA sensors; ANTIPROLIFERATIVE ACTIVITY; ANTICANCER DRUGS; CANCER; INHIBITION; ACRIDINYLIDENE; PROLIFERATION; DESIGN; TARGET; AGENTS;

D O I：

10.1016/j.bmc.2012.04.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Although their exact role in controlling tumour growth and apoptosis in humans remains undefined, acridine and thiazolidine compounds have been shown to act as tumour suppressors in most cancers. Based on this finding, a series of novel hybrid 5-acridin-9-ylmethylene-3-benzyl-thiazolidine-2,4-diones were synthesised via N-alkylation and Michael reaction. The cell viability was analysed using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and DNA interaction assays were performed using electrochemical techniques. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：3533 / 3539

页数：7

共 45 条

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A NEW RAPID AND SIMPLE NONRADIOACTIVE ASSAY TO MONITOR AND DETERMINE THE PROLIFERATION OF LYMPHOCYTES - AN ALTERNATIVE TO [H-3] THYMIDINE INCORPORATION ASSAY [J].