Aquaporin 1 is an independent prognostic factor in pleural malignant mesothelioma

被引:48
作者
Kao, Steven Chuan-Hao [1 ,2 ,3 ]
Armstrong, Nicola [4 ,5 ]
Condon, Bridget
Griggs, Kim [7 ]
McCaughan, Brian [8 ]
Maltby, Sarah [6 ]
Wilson, Alan [6 ]
Henderson, Douglas W. [6 ,7 ]
Klebe, Sonja [6 ,7 ]
机构
[1] Bernie Banton Ctr, Asbestos Dis Res Inst, Rhodes, NSW, Australia
[2] Concord Repatriat Gen Hosp, Dept Med Oncol, Concord, NSW, Australia
[3] Univ Sydney, Sch Med, Sydney, NSW 2006, Australia
[4] Garvan Inst Med Res, Canc Res Program, Sydney, NSW, Australia
[5] Univ New S Wales, Sch Math & Stat, Kensington, NSW 2033, Australia
[6] Flinders Univ S Australia, Sch Med, Adelaide, SA, Australia
[7] Flinders Med Ctr, SA Pathol, Dept Surg Pathol, Bedford Pk, SA 5042, Australia
[8] Royal Prince Alfred Hosp, Dept Cardiothorac Surg, Camperdown, NSW 2050, Australia
基金
英国医学研究理事会;
关键词
malignant mesothelioma; aquaporin; 1; prognosis; PREDICTIVE ACCURACY; WATER CHANNELS; EXPRESSION; SURVIVAL; CANCER; LUNG; OVEREXPRESSION; EDEMA;
D O I
10.1002/cncr.26497
中图分类号
R73 [肿瘤学];
学科分类号
100214 [肿瘤学];
摘要
BACKGROUND: Malignant mesothelioma (MM) is an aggressive cancer of serosal membranes, mostly pleura. It is related to asbestos exposure and its incidence in most industrialized countries is projected to remain stable or to increase until 2020. Prognosis remains poor. Clinical prognostic scoring systems lack precision. No prognostic tissue markers are available. Aquaporin 1 (AQP1) is a cell membrane channel involved in water transport, cell motility, and proliferation. A blocker and an agonist are available. METHODS: Two independent cohorts of MM were studied. Cohort 1 consisted of 80 consecutive patients who underwent radical surgery (extrapleural pneumonectomy [EPP]). Cohort 2 included 56 conservatively managed patients from another institution. Clinical information was obtained from files. Diagnoses were histologically verified. Immunohistochemical labeling for AQP1 was performed on tumor tissue and the percentage of positive cells was scored. RESULTS: We demonstrated expression of AQP1 in normal and neoplastic mesothelium at the apical aspect of the cell, in keeping with a role in water transport. For both cohorts, expression of AQP1 by =50% of tumor cells was associated with significantly enhanced survival (9.4 months vs 30.4 months in EPP patients and 5 months vs 15 months in conservatively treated patients). This was independent of established prognostic factors, including histologic subtype, pathologic stage, sex, and age at time of diagnosis. CONCLUSION: Expression of AQP1 correlated significantly with prognosis in MM, irrespective of treatment or established prognostic factors. Immunohistochemical labeling for AQP1 should be included in the routine histopathologic workup. An agonist or blocker may become useful for treatment. Cancer 2011;. (c) 2011 American Cancer Society.
引用
收藏
页码:2952 / 2961
页数:10
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