SARS-CoV-2: a storm is raging

被引：829

作者：

Pedersen, Savannah F. ^{[1
]}

Ho, Ya-Chi ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Microbial Pathogenesis, New Haven, CT 06519 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2020年 / 130卷 / 05期

关键词：

D O I：

10.1172/JCI137647

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10, and TNF-alpha), lymphopenia (in CD4(+) and CD8(+) T cells), and decreased IFN-gamma expression in CD4(+) T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design.

引用

页码：2202 / 2205

页数：4

共 18 条

[1] Presumed Asymptomatic Carrier Transmission of COVID-19 [J].

Bai, Yan ;

Yao, Lingsheng ;

Wei, Tao ;

Tian, Fei ;

Jin, Dong-Yan ;

Chen, Lijuan ;

Wang, Meiyun .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (14) :1406-1407

[2] A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster [J].

Chan, Jasper Fuk-Woo ;

Yuan, Shuofeng ;

Kok, Kin-Hang ;

To, Kelvin Kai-Wang ;

Chu, Hin ;

Yang, Jin ;

Xing, Fanfan ;

Liu, Jieling ;

Yip, Cyril Chik-Yan ;

Poon, Rosana Wing-Shan ;

Tsoi, Hoi-Wah ;

Lo, Simon Kam-Fai ;

Chan, Kwok-Hung ;

Poon, Vincent Kwok-Man ;

Chan, Wan-Mui ;

Ip, Jonathan Daniel ;

Cai, Jian-Piao ;

Cheng, Vincent Chi-Chung ;

Chen, Honglin ;

Hui, Christopher Kim-Ming ;

Yuen, Kwok-Yung .

LANCET, 2020, 395 (10223) :514-523

[3] Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology [J].

Channappanavar, Rudragouda ;

Perlman, Stanley .

SEMINARS IN IMMUNOPATHOLOGY, 2017, 39 (05) :529-539

[4] Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice [J].

Channappanavar, Rudragouda ;

Fehr, Anthony R. ;

Vijay, Rahul ;

Mack, Matthias ;

Zhao, Jincun ;

Meyerholz, David K. ;

Perlman, Stanley .

CELL HOST & MICROBE, 2016, 19 (02) :181-193

[5] Clinical and immunological features of severe and moderate coronavirus disease 2019 [J].

Chen, Guang ;

Wu, Di ;

Guo, Wei ;

Cao, Yong ;

Huang, Da ;

Wang, Hongwu ;

Wang, Tao ;

Zhang, Xiaoyun ;

Chen, Huilong ;

Yu, Haijing ;

Zhang, Xiaoping ;

Zhang, Minxia ;

Wu, Shiji ;

Song, Jianxin ;

Chen, Tao ;

Han, Meifang ;

Li, Shusheng ;

Luo, Xiaoping ;

Zhao, Jianping ;

Ning, Qin .

JOURNAL OF CLINICAL INVESTIGATION, 2020, 130 (05) :2620-2629

[6] Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19) [J].

Diao, Bo ;

Wang, Chenhui ;

Tan, Yingjun ;

Chen, Xiewan ;

Liu, Ying ;

Ning, Lifen ;

Chen, Li ;

Li, Min ;

Liu, Yueping ;

Wang, Gang ;

Yuan, Zilin ;

Feng, Zeqing ;

Zhang, Yi ;

Wu, Yuzhang ;

Chen, Yongwen .

FRONTIERS IN IMMUNOLOGY, 2020, 11

[7] A decade after SARS: strategies for controlling emerging coronaviruses [J].

Graham, Rachel L. ;

Donaldson, Eric F. ;

Baric, Ralph S. .

NATURE REVIEWS MICROBIOLOGY, 2013, 11 (12) :836-848

[8] Clinical Characteristics of Coronavirus Disease 2019 in China [J].

Guan, W. ;

Ni, Z. ;

Hu, Yu ;

Liang, W. ;

Ou, C. ;

He, J. ;

Liu, L. ;

Shan, H. ;

Lei, C. ;

Hui, D. S. C. ;

Du, B. ;

Li, L. ;

Zeng, G. ;

Yuen, K. -Y. ;

Chen, R. ;

Tang, C. ;

Wang, T. ;

Chen, P. ;

Xiang, J. ;

Li, S. ;

Wang, Jin-lin ;

Liang, Z. ;

Peng, Y. ;

Wei, L. ;

Liu, Y. ;

Hu, Ya-hua ;

Peng, P. ;

Wang, Jian-ming ;

Liu, J. ;

Chen, Z. ;

Li, G. ;

Zheng, Z. ;

Qiu, S. ;

Luo, J. ;

Ye, C. ;

Zhu, S. ;

Zhong, N. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (18) :1708-1720

[9]

Huang CL, 2020, LANCET, V395, P497, DOI [10.1016/S0140-6736(20)30183-5, 10.1016/S0140-6736(20)30211-7]

[10]

Li Q., 2020, N. Engl. J. Med., V382, P1199, DOI [DOI 10.1056/NEJMOA2001316, DOI 10.1056/NEJMoa2001316, 10.1056/NEJMoa2001316]

← 1 2 →