Rotavirus genotypes in children in the Basque Country (North of Spain): rapid and intense emergence of the G12[P8] genotype

被引:39
作者
Cilla, G. [1 ]
Montes, M. [1 ]
Gomariz, M. [1 ]
Alkorta, M. [2 ]
Iturzaeta, A. [2 ]
Perez-Yarza, E. G. [3 ,4 ]
Perez-Trallero, E. [1 ,4 ]
机构
[1] Hosp Univ Donostia, Serv Microbiol, Inst BioDonostia, San Sebastian 20014, Spain
[2] Hosp Zumarraga, Serv Microbiol, Zumarraga, Spain
[3] Hosp Univ Donostia, Serv Pediat, San Sebastian 20014, Spain
[4] Basque Country Univ UPV EHU, Fac Med, San Sebastian, Spain
关键词
Epidemic; genotypes; rotavirus; rotavirus G12; rotavirus surveillance; UNITED-STATES; MOLECULAR EPIDEMIOLOGY; G12; ROTAVIRUSES; STRAINS; DIARRHEA; GASTROENTERITIS; SURVEILLANCE; SPECIFICITY; ARGENTINA; EUROPE;
D O I
10.1017/S0950268812001306
中图分类号
R1 [预防医学、卫生学];
学科分类号
100235 [预防医学];
摘要
Between July 2009 and June 2011, rotavirus was detected in 507 of 4597 episodes of acute gastroenteritis in children aged < 3 years in Gipuzkoa (Basque Country, Spain), of which the G-type was determined in 458 (90.3%). During the annual seasonal epidemic of 2010-2011, the unusual G-type 12 was predominant, causing 65% (145/223) of cases of rotavirus gastroenteritis. All the G12 strains were clustered in lineage III and were preferentially associated with P-type 8. This epidemic was characterized by broad geographical distribution (rural and urban) and, over 7 months, affected both infants and children, the most frequently affected being children between 4 and 24 months. Of children with rotavirus G12, 16% required hospital admission, the admission rate in children aged < 2 years being 20.7 cases/10 000 children. The sudden emergence and predominance of G12 rotaviruses documented in this winter outbreak suggest that they may soon become a major human rotavirus genotype.
引用
收藏
页码:868 / 874
页数:7
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