Oxygen-Mediated Regulation of Biofilm Development Is Controlled by the Alternative Sigma Factor σB in Staphylococcus epidermidis

被引：30

作者：

Cotter, John J. ^{[1
]}

O'Gara, James P. ^{[2
]}

Mack, Dietrich ^{[3
]}

Casey, Eoin ^{[1
]}

机构：

[1] Univ Coll Dublin, Ctr Synth & Chem Biol, UCD Sch Chem & Bioproc Engn, Dublin 4, Ireland

[2] Univ Coll Dublin, UCD Sch Biomed & Biomol Sci, Dublin 4, Ireland

[3] Swansea Univ, Sch Med, Inst Life Sci, Swansea, W Glam, Wales

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2009年 / 75卷 / 01期

基金：

爱尔兰科学基金会;

关键词：

POLYSACCHARIDE INTERCELLULAR ADHESIN; ENVIRONMENTAL-REGULATION; ICA LOCUS; EXPRESSION; AUREUS; STRAINS; TRANSCRIPTION; RSBU; MECHANISMS; COMMENSAL;

D O I：

10.1128/AEM.00261-08

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Using a modified rotating-disk reactor to sparge oxygen to Staphylococcus epidermidis cultures, we found that oxygen negatively regulates biofilm development by influencing the activity of sigma(B). Under anaerobic conditions, increased sigma(B) activity activates icaADBC, which encodes enzymes responsible for polysaccharide intercellular adhesin synthesis, by repressing transcription of the negative regulator icaR.

引用

页码：261 / 264

页数：4

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