Notch signaling in hematopoietic stem cells

被引：51

作者：

Suzuki, T

Chiba, S

机构：

[1] Tokyo Univ Hosp, Dept Cell Therapy & Transplantat Med, Bunkyo Ku, Tokyo 1138655, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Regenerat Med Hematopoiesis, Tokyo, Japan

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2005年 / 82卷 / 04期

关键词：

Notch; hematopoietic stem cell; hematopoietic development; niche;

D O I：

10.1532/IJH97.05115

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The molecular basis of the hematopoietic stem cell (HSC) "niche" has gradually been elucidated. This new knowledge may help us understand how the self-renewal of HSCs is physiologically regulated and may give us clues for developing methods for ex vivo HSC expansion. The Notch pathway is all environmental signaling system that may play an important role ill the HSC niche. In this review. we focus on the role of Notch signaling in the regulation of hematopoietic stem and progenitor cells in both embryo and adult hematopoiesis and clarify what is known regarding the self-renewal of HSCs.

引用

收藏

页码：285 / 294

页数：10

相关论文

共 109 条

[1] Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes [J].

Anastasi, E ;

Campese, AF ;

Bellavia, D ;

Bulotta, A ;

Balestri, A ;

Pascucci, M ;

Checquolo, S ;

Gradini, R ;

Lendahl, U ;

Frati, L ;

Gulino, A ;

Di Mario, U ;

Screpanti, I .

JOURNAL OF IMMUNOLOGY, 2003, 171 (09) :4504-4511

[2] Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche [J].

Arai, F ;

Hirao, A ;

Ohmura, M ;

Sato, H ;

Matsuoka, S ;

Takubo, K ;

Ito, K ;

Koh, GY ;

Suda, T .

CELL, 2004, 118 (02) :149-161

[3] Notch signaling: Cell fate control and signal integration in development [J].

Artavanis-Tsakonas, S ;

Rand, MD ;

Lake, RJ .

SCIENCE, 1999, 284 (5415) :770-776

[4] An overview of the Notch signalling pathway [J].

Baron, M .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2003, 14 (02) :113-119

[5] Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice [J].

Bellavia, D ;

Campese, AF ;

Alesse, E ;

Vacca, A ;

Felli, MP ;

Balestri, A ;

Stoppacciaro, A ;

Tiveron, C ;

Tatangelo, L ;

Giovarelli, M ;

Gaetano, C ;

Ruco, L ;

Hoffman, ES ;

Hayday, AC ;

Lendahl, U ;

Frati, L ;

Gulino, A ;

Screpanti, I .

EMBO JOURNAL, 2000, 19 (13) :3337-3348

[6] Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation [J].

Bhardwaj, G ;

Murdoch, B ;

Wu, D ;

Baker, DP ;

Williams, KP ;

Chadwick, K ;

Ling, LE ;

Karanu, FN ;

Bhatia, M .

NATURE IMMUNOLOGY, 2001, 2 (02) :172-180

[7] Bone morphogenetic proteins regulate the developmental program of human hematopoietic stem cells [J].

Bhatia, M ;

Bonnet, D ;

Wu, DM ;

Murdoch, B ;

Wrana, J ;

Gallacher, L ;

Dick, JE .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (07) :1139-1147

[8] Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines [J].

Bigas, A ;

Martin, DIK ;

Milner, LA .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (04) :2324-2333

[9] Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo [J].

Cai, ZL ;

de Bruijn, M ;

Ma, XQ ;

Dortland, B ;

Luteijn, T ;

Downing, JR ;

Dzierzak, E .

IMMUNITY, 2000, 13 (04) :423-431

[10] Osteoblastic cells regulate the haematopoietic stem cell niche [J].

Calvi, LM ;

Adams, GB ;

Weibrecht, KW ;

Weber, JM ;

Olson, DP ;

Knight, MC ;

Martin, RP ;

Schipani, E ;

Divieti, P ;

Bringhurst, FR ;

Milner, LA ;

Kronenberg, HM ;

Scadden, DT .

NATURE, 2003, 425 (6960) :841-846

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