The Active Ingredients of Jiang-Zhi-Ning: Study of the Nelumbo nucifera Alkaloids and Their Main Bioactive Metabolites

被引：14

作者：

Chen, Jianxin ^{[1
]}

Ma, Xueling ^{[1
]}

Gao, Kuo ^{[1
]}

Wang, Yong ^{[1
]}

Zhao, Huihui ^{[1
]}

Wu, Hao ^{[1
]}

Wang, Juan ^{[1
]}

Xie, Hua ^{[1
]}

OuYang, Yulin ^{[1
]}

Luo, Liangtao ^{[1
]}

Guo, Shuzhen ^{[1
]}

Han, Jing ^{[1
]}

Liu, Bing ^{[1
]}

Wang, Wei ^{[1
]}

机构：

[1] Beijing Univ Chinese Med, Beijing 100029, Peoples R China

来源：

MOLECULES | 2012年 / 17卷 / 08期

基金：

美国国家科学基金会;

关键词：

Nelumbo nucifera; alkaloids; Jiang-Zhi-Ning; substantial basis of Traditional Chinese Medicine; 2-hydroxy-1-methoxyaporphin; APORPHINE ALKALOIDS;

D O I：

10.3390/molecules17089855

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The object of this study was to identify the major active ingredients of the Chinese Traditional Medicine Jiang-Zhi-Ning (JZN) based on the high performance liquid chromatography (HPLC) profiles of plasma samples obtained from beagle dogs at different times after intragastric administration of JZN, crude JZN extracts, different extracted fractions, different subfractions of the active fraction and different isolated ingredients. 2-Hydroxy-1-methoxyaporphin (2H1M), an alkaloid from Nelumbo nucifera, one of the herbs that make up JZN, was identified as the constituent showing the major pharmacodynamic effect. The major metabolites of 2H1M were analyzed and identified as N-demethyl-2-hydroxy-1-methoxyaporphine-2-O-glycuronic acid, 2-hydroxy-1-methoxyaporphine-2-O-glycuronic acid and 2-hydroxy-1-methoxy-aporphine-2-O-sulphate. This study provided a comprehensive insight into the active components of JZN.

引用

页码：9855 / 9867

页数：13

共 16 条

[1]

Antipoliovirus structure-activity relationships of some aporphine alkaloids [J].

Boustie, J ;

Stigliani, JL ;

Montanha, J ;

Amoros, M ;

Payard, P ;

Girre, L .

JOURNAL OF NATURAL PRODUCTS, 1998, 61 (04) :480-484

[2]

Lipid-lowering and antioxidant activities of Jiang-Zhi-Ning in Traditional Chinese Medicine [J].

Chen, Jianxin ;

Zhao, Huihui ;

Yang, Ying ;

Liu, Bing ;

Ni, Jian ;

Wang, Wei .

JOURNAL OF ETHNOPHARMACOLOGY, 2011, 134 (03) :919-930

[3]

Guan J.H., 2002, ZHONGGUO ZHONG YAO Z, P27

[4]

Guan Jian-hong, 2002, Zhongguo Zhongyao Zazhi, V27, P289

[5]

Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids [J].

Kashiwada, Y ;

Aoshima, A ;

Ikeshiro, Y ;

Chen, YP ;

Furukawa, H ;

Itoigawa, M ;

Fujioka, T ;

Mihashi, K ;

Cosentino, LM ;

Morris-Natschke, SL ;

Lee, KH .

BIOORGANIC & MEDICINAL CHEMISTRY, 2005, 13 (02) :443-448

[6]

STUDIES ON ALKALOIDS OF NELUMBO-NUCIFERA GAERTN .16. ALKALOIDS OF NELUMBO-NUCIFERA [J].

KUNITOMO, J ;

YOSHIKAW.Y ;

TANAKA, S ;

IMORI, Y ;

ISOI, K .

PHYTOCHEMISTRY, 1973, 12 (03) :699-701

[7]

Lin M B, 1982, Yao Xue Xue Bao, V17, P728

[8]

Lv C.Y., 2006, CHIN PHARM J, V41, P241

[9]

Application of ionic liquids based microwave-assisted extraction of three alkaloids N-nornuciferine, O-nornuciferine, and nuciferine from lotus leaf [J].

Ma, Wenyan ;

Lu, Yanbin ;

Hu, Ruilin ;

Chen, Jihang ;

Zhang, Zizhang ;

Pan, Yuanjiang .

TALANTA, 2010, 80 (03) :1292-1297

[10]

Cytotoxic and antiviral activities of aporphine alkaloids of Magnolia grandiflora L. [J].

Mohamed, S. M. ;

Hassan, E. M. ;

Ibrahim, N. A. .

NATURAL PRODUCT RESEARCH, 2010, 24 (15) :1395-1402

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