Confirmation of the mapping of a 12-O-tetradecanoylphorbol-13-acetate promotion susceptibility locus, Psl1, to distal mouse chromsome 9

被引：8

作者：

Angel, JM ^{[1
]}

Caballero, M ^{[1
]}

DiGiovanni, J ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Div Res, Smithville, TX 78957 USA

来源：

MOLECULAR CARCINOGENESIS | 2001年 / 32卷 / 04期

关键词：

chemical carcinogenesis; tumor susceptibility genes; complex genetic traits; skin tumor promotion;

D O I：

10.1002/mc.10010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Susceptibility to two-stage skin carcinogenesis in the mouse is affected by several genes. In addition, studies suggest that genes that modify the response of mice to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) also may influence histologic changes in the skin as the result of TPA treatment. One TPA susceptibility locus, Ps/1, previously was mapped to distal chromosome 9. The mapping of this locus was confirmed by marker-based genotypic selection. Furthermore, Ps/1 or a gene closely linked to Ps/1 influenced epidermal hyperplasia and epidermal labeling index of mice treated with TPA. (C) 2001 Wiley-Liss, Inc.

引用

页码：169 / 175

页数：7

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