Targeting DNA Methylation and EZH2 Activity to Overcome Melanoma Resistance to Immunotherapy

被引：185

作者：

Al Emran, Abdullah ^{[1
]}

Chatterjee, Aniruddha ^{[2
,3
]}

Rodger, Euan J. ^{[2
,3
]}

Tiffen, Jessamy C. ^{[1
]}

Gallagher, Stuart J. ^{[1
]}

Eccles, Michael R. ^{[2
,3
]}

Hersey, Peter ^{[1
]}

机构：

[1] Univ Sydney, Royal Prince Alfred Hosp, Centenary Inst, Melanoma Immunol & Oncol Grp, Camperdown, NSW 2050, Australia

[2] Univ Otago, Dunedin Sch Med, Dept Pathol, 270 Great King St, Dunedin 9054, New Zealand

[3] Maurice Wilkins Ctr Mol Biodiscovery, Level,3A Symonds St, Auckland, New Zealand

来源：

TRENDS IN IMMUNOLOGY | 2019年 / 40卷 / 04期

基金：

英国医学研究理事会;

关键词：

CD8; T-CELLS; SILENCED GENES; STAGE-III; CANCER; EXPRESSION; PD-1; INHIBITOR; CHROMATIN; DIFFERENTIATION; PATHWAYS;

D O I：

10.1016/j.it.2019.02.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Methylation of DNA at CpG sites is the most common and stable of epigenetic changes in cancer. Hypermethylation acts to limit immune checkpoint blockade immunotherapy by inhibiting endogenous interferon responses needed for recognition of cancer cells. By contrast, global hypomethylation results in the expression of programmed death ligand 1 (PD-L1) and inhibitory cytokines, accompanied by epithelial-mesenchymal changes that can contribute to immunosuppression. The drivers of these contrasting methylation states are not well understood. DNA methylation also plays a key role in cytotoxic T cell 'exhaustion' associated with tumor progression. We present an updated exploratory analysis of how DNA methylation may define patient subgroups and can be targeted to develop tailored treatment combinations to help improve patient outcomes.

引用

页码：328 / 344

页数：17

共 116 条

[1]

Demethylation of the PD-1 Promoter Is Imprinted during the Effector Phase of CD8 T Cell Exhaustion [J].

Ahn, Eunseon ;

Youngblood, Ben ;

Lee, Junghwa ;

Lee, Judong ;

Sarkar, Surojit ;

Ahmed, Rafi .

JOURNAL OF VIROLOGY, 2016, 90 (19) :8934-8946

[2]

Genomic Classification of Cutaneous Melanoma [J].

Akbani, Rehan ;

Akdemir, Kadir C. ;

Aksoy, B. Arman ;

Albert, Monique ;

Ally, Adrian ;

Amin, Samirkumar B. ;

Arachchi, Harindra ;

Arora, Arshi ;

Auman, J. Todd ;

Ayala, Brenda ;

Baboud, Julien ;

Balasundaram, Miruna ;

Balu, Saianand ;

Barnabas, Nandita ;

Bartlett, John ;

Bartlett, Pam ;

Bastian, Boris C. ;

Baylin, Stephen B. ;

Behera, Madhusmita ;

Belyaev, Dmitry ;

Benz, Christopher ;

Bernard, Brady ;

Beroukhim, Rameen ;

Bir, Natalie ;

Black, Aaron D. ;

Bodenheimer, Tom ;

Boice, Lori ;

Boland, Genevieve M. ;

Bono, Riccardo ;

Bootwalla, Moiz S. ;

Bosenberg, Marcus ;

Bowen, Jay ;

Bowlby, Reanne ;

Bristow, Christopher A. ;

Brockway-Lunardi, Laura ;

Brooks, Denise ;

Brzezinski, Jakub ;

Bshara, Wiam ;

Buda, Elizabeth ;

Burns, William R. ;

Butterfield, Yaron S. N. ;

Button, Michael ;

Calderone, Tiffany ;

Cappellini, Giancarlo Antonini ;

Carter, Candace ;

Carter, Scott L. ;

Cherney, Lynn ;

Cherniack, Andrew D. ;

Chevalier, Aaron ;

Chin, Lynda .

CELL, 2015, 161 (07) :1681-1696

[3]

Origin and differentiation of human memory CD8 T cells after vaccination [J].

Akondy, Rama S. ;

Fitch, Mark ;

Edupuganti, Srilatha ;

Yang, Shu ;

Kissick, Haydn T. ;

Li, Kelvin W. ;

Youngblood, Ben A. ;

Abdelsamed, Hossam A. ;

McGuire, Donald J. ;

Cohen, Kristen W. ;

Alexe, Gabriela ;

Nagar, Shashi ;

McCausland, Megan M. ;

Gupta, Satish ;

Tata, Pramila ;

Haining, W. Nicholas ;

McElrath, M. Juliana ;

Zhang, David ;

Hu, Bin ;

Greenleaf, William J. ;

Goronzy, Jorg J. ;

Mulligan, Mark J. ;

Hellerstein, Marc ;

Ahmed, Rafi .

NATURE, 2017, 552 (7685) :362-+

[4]

Consensus nomenclature for CD8+ T cell phenotypes in cancer [J].

Apetoh, Lionel ;

Smyth, Mark J. ;

Drake, Charles G. ;

Abastado, Jean-Pierre ;

Apte, Ron N. ;

Ayyoub, Maha ;

Blay, Jean-Yves ;

Bonneville, Marc ;

Butterfield, Lisa H. ;

Caignard, Anne ;

Castelli, Chiara ;

Cavallo, Federica ;

Celis, Esteban ;

Chen, Lieping ;

Colombo, Mario P. ;

Comin-Anduix, Begona ;

Coukos, Georges ;

Dhodapkar, Madhav V. ;

Dranoff, Glenn ;

Frazer, Ian H. ;

Fridman, Wolf-Herve ;

Gabrilovich, Dmitry I. ;

Gilboa, Eli ;

Gnjatic, Sacha ;

Jaeger, Dirk ;

Kalinski, Pawel ;

Kaufman, Howard L. ;

Kiessling, Rolf ;

Kirkwood, John ;

Knuth, Alexander ;

Liblau, Roland ;

Lotze, Michael T. ;

Lugli, Enrico ;

Marincola, Francesco ;

Melero, Ignacio ;

Melief, Cornelis J. ;

Mempel, Thorsten R. ;

Mittendorf, Elizabeth A. ;

Odun, Kunle ;

Overwijk, Willem W. ;

Palucka, Anna Karolina ;

Parmiani, Giorgio ;

Ribas, Antoni ;

Romero, Pedro ;

Schreiber, Robert D. ;

Schuler, Gerold ;

Srivastava, Pramod K. ;

Tartour, Eric ;

Valmori, Danila ;

van der Burg, Sjoerd H. .

ONCOIMMUNOLOGY, 2015, 4 (04)

[5]

Emerging roles for chromatin as a signal integration and storage platform [J].

Badeaux, Aimee I. ;

Shi, Yang .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2013, 14 (04) :211-224

[6]

YY1 Upregulates Checkpoint Receptors and Downregulates Type I Cytokines in Exhausted, Chronically Stimulated Human T Cells [J].

Balkhi, Mumtaz Y. ;

Wittmann, Gabor ;

Xiong, Fang ;

Junghans, Richard P. .

ISCIENCE, 2018, 2 :105-+

[7]

Increased CD4+ T cell lineage commitment determined by CpG methylation correlates with better prognosis in urinary bladder cancer patients [J].

Bergman, Emma Ahlen ;

Hartana, Ciputra Adijaya ;

Johansson, Markus ;

Linton, Ludvig B. ;

Berglund, Sofia ;

Hyllienmark, Martin ;

Lundgren, Christian ;

Holmstrom, Benny ;

Palmqvist, Karin ;

Hansson, Johan ;

Alamdari, Farhood ;

Huge, Ylva ;

Aljabery, Firas ;

Riklund, Katrine ;

Winerdal, Malin E. ;

Krantz, David ;

Zirakzadeh, A. Ali ;

Marits, Per ;

Sjoholm, Louise K. ;

Sherif, Amir ;

Winqvist, Ola .

CLINICAL EPIGENETICS, 2018, 10

[8]

The class I/IV HDAC inhibitor mocetinostat increases tumor antigen presentation, decreases immune suppressive cell types and augments checkpoint inhibitor therapy [J].

Briere, David ;

Sudhakar, Niranjan ;

Woods, David M. ;

Hallin, Jill ;

Engstrom, Lars D. ;

Aranda, Ruth ;

Chiang, Harrah ;

Sodre, Andressa L. ;

Olson, Peter ;

Weber, Jeffrey S. ;

Christensen, James G. .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2018, 67 (03) :381-392

[9]

Plasticity of Type I Interferon-Mediated Responses in Cancer Therapy: From Anti-tumor Immunity to Resistance [J].

Budhwani, Megha ;

Mazzieri, Roberta ;

Dolcetti, Riccardo .

FRONTIERS IN ONCOLOGY, 2018, 8

[10]

Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses [J].

Canadas, Israel ;

Thummalapalli, Rohit ;

Kim, Jong Wook ;

Kitajima, Shunsuke ;

Jenkins, Russell William ;

Christensen, Camilla Laulund ;

Campisi, Marco ;

Kuang, Yanan ;

Zhang, Yanxi ;

Gjini, Evisa ;

Zhang, Gao ;

Tian, Tian ;

Sen, Debattama Rai ;

Miao, Diana ;

Imamura, Yu ;

Tran Thai ;

Piel, Brandon ;

Terai, Hideki ;

Aref, Amir Reza ;

Hagan, Timothy ;

Koyama, Shohei ;

Watanabe, Masayuki ;

Baba, Hideo ;

Adeni, Anika Elise ;

Lydon, Christine Anne ;

Tamayo, Pablo ;

Wei, Zhi ;

Herlyn, Meenhard ;

Barbie, Thanh Uyen ;

Uppaluri, Ravindra ;

Sholl, Lynnette Marie ;

Sicinska, Ewa ;

Sands, Jacob ;

Rodig, Scott ;

Wong, Kwok Kin ;

Paweletz, Cloud Peter ;

Watanabe, Hideo ;

Barbie, David Allen .

NATURE MEDICINE, 2018, 24 (08) :1143-+

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