The kynurenine metabolic pathway in the eye: studies on 3-hydroxykynurenine, a putative cataractogenic compound

被引:26
作者
Chiarugia, A
Rapizzi, E
Moroni, F
Moroni, F
机构
[1] Univ Florence, Dept Preclin & Clin Pharmacol, I-50139 Florence, Italy
[2] Emory Univ, Ctr Eye, Atlanta, GA 30322 USA
[3] Univ Florence, Ophthalmol Clin, Florence, Italy
关键词
tryptophan metabolism; kynurenine; lens; iris ciliary body; cataract; 3-hydroxykynurenine; kynurenine hydroxylase;
D O I
10.1016/S0014-5793(99)00724-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The rabbit lens has an elevated content of 3-hydroxykynurenine (3OHKYN) in spite of a very low activity of the enzymes leading to its synthesis. The iris/ciliary body, on the contrary, has very high activity of 3OHKYN synthesizing enzymes but a content of 3OHKYN lower than that of the lens. These observations suggest that 3OHKYN is formed in the iris/ciliary body, released into the aqueous humor and then taken up into the lens where it may be used for the synthesis of UV filtering products. An excessive accumulation of 3OHKYN in the lens has been associated with cataract formation. We found that available selective inhibitors of kynurenine hydroxylase reduced 3OHKYN synthesis in both the lens and the iris/ciliary body. (C) 1999 Federation of European Biochemical Societies.
引用
收藏
页码:197 / 200
页数:4
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