Chemical development of NBI-75043. Use of a flow reactor to circumvent a batch-limited metal-halogen exchange reaction

被引：22

作者：

Gross, Timothy D. ^{[1
]}

Chou, Shine ^{[1
]}

Bonneville, Daniel ^{[1
]}

Gross, Raymond S. ^{[1
]}

Wang, Peng ^{[1
]}

Campopiano, Onorato ^{[1
]}

Ouellette, Michael A. ^{[1
]}

Zook, Scott E. ^{[1
]}

Reddy, Jayachandra P. ^{[1
]}

Moree, Wilna J. ^{[1
]}

Jovic, Florence ^{[1
]}

Chopade, Shubham ^{[2
]}

机构：

[1] Neurocrine Biosci Inc, Chem Dev & Med Chem, San Diego, CA 92130 USA

[2] Irix Pharmaceut Inc, Florence, SC 29501 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2008年 / 12卷 / 05期

关键词：

D O I：

10.1021/op800071m

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The discovery route and subsequent scale-up routes for NBI-75043 are presented. When traditional batch chemistry was found to limit the scale of a key reaction, a flow reactor was designed and optimized to provide an alternate method of production.

引用

页码：929 / 939

页数：11

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