Candidate autoantigens in multiple sclerosis

被引：58

作者：

Schmidt, S ^{[1
]}

机构：

[1] Univ Bonn, Dept Neurol, D-53105 Bonn, Germany

来源：

MULTIPLE SCLEROSIS JOURNAL | 1999年 / 5卷 / 03期

关键词：

multiple sclerosis; autoantigens; myelin; T cells; B cells;

D O I：

10.1177/135245859900500303

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Multiple sclerosis is an inflammatory demyelinating CNS disease of putatively autoimmune origin. Novel models of experimental autoimmune encephalomyelitis (EAE) have demonstrated that T cells specific for various myelin and even nonmyelin proteins ore potentially encephalitogenic The encephalitogenic T cell response directed against different CNS antigens not only determines the lesional topography of CNS inflammation but also the composition of the inflammatory infiltrates. The heterogeneity of the lesional distribution seen in EAE might therefore be useful for the understanding of the various clinical subtypes seen in MS. In this review the Possible candidate autoantigens in MS are discussed with special regard to the human T cell and B cell responses against various myelin and nonmyelin proteins.

引用

页码：147 / 160

页数：14

共 166 条

[1] The N-terminal domain of the myelin oligodendrocyte glycoprotein (MOG) induces acute demyelinating experimental autoimmune encephalomyelitis in the Lewis rat [J].