The CD39-Adenosinergic Axis in the Pathogenesis of Immune and Nonimmune Diabetes

被引：16

作者：

Chia, Joanne S. J. ^{[1
,2
]}

McRae, Jennifer L. ^{[1
]}

Cowan, Peter J. ^{[1
,2
]}

Dwyer, Karen M. ^{[1
,2
]}

机构：

[1] St Vincents Hosp Melbourne, Immunol Res Ctr, Fitzroy, Vic 3065, Australia

[2] Univ Melbourne, Dept Med, Parkville, Vic 3010, Australia

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2012年

关键词：

ISCHEMIA-REPERFUSION INJURY; MEDIATED TISSUE PROTECTION; ADENOSINE-RECEPTOR; T-CELLS; INSULIN-RESISTANCE; EXTRACELLULAR ATP; GLUCAGON-SECRETION; A(2B) RECEPTORS; BETA-CELLS; TREG CELLS;

D O I：

10.1155/2012/320495

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Diabetes mellitus encompasses two distinct disease processes: autoimmune Type 1 (T1D) and nonimmune Type 2 (T2D) diabetes. Despite the disparate aetiologies, the disease phenotype of hyperglycemia and the associated complications are similar. In this paper, we discuss the role of the CD39-adenosinergic axis in the pathogenesis of both T1D and T2D, with particular emphasis on the role of CD39 and CD73.

引用

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