Reactions of 2-methyl-3,1-benzoxazin-4-one with active methylene compounds: A new route to 3-substituted 4-hydroxyquinolin-2(1H)-ones

被引：44

作者：

Detsi, A

Bardakos, V

Markopoulos, J

IgglessiMarkopoulou, O

机构：

[1] NATL TECH UNIV ATHENS,DEPT CHEM ENGN,ORGAN CHEM LAB,GR-15773 ATHENS,GREECE

[2] UNIV ATHENS,DEPT CHEM,GR-10679 ATHENS,GREECE

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1996年 / 24期

关键词：

D O I：

10.1039/p19960002909

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new route to 3-substituted 4-hydroxyquinolin-2(1H)-ones, compounds of great biological importance, is described. The C-acylation of active methylene compounds 2 with the 2-methyl-3,1-benzoxazin-4-one 1, under basic conditions, leads to the formation of the new products 3-10, which have been isolated and characterized. Cyclization of the above intermediates furnishes the 3-substituted 4-hydroxyquinolin-2(1H)-ones. Spectral data and physical characteristics for all compounds are reported.

引用

页码：2909 / 2913

页数：5

共 33 条

[1]

BARKLEY JV, 1994, J CHEM SOC PERK T 2, P1271

[2]

BRAVO P, 1986, J CHEM RES-S, P374

[3] 3-NITRO-3,4-DIHYDRO-2(1H)-QUINOLONES - EXCITATORY AMINO-ACID ANTAGONISTS ACTING AT GLYCINE-SITE NMDA AND (RS)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID RECEPTORS [J].