Stem cell therapies for acute spinal cord injury in humans: a review

被引：112

作者：

Jin, Michael C. ^{[1
]}

Medress, Zachary A. ^{[1
]}

Azad, Tej D. ^{[1
]}

Doulames, Vanessa M. ^{[1
]}

Veeravagu, Anand ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Neurosurg, Stanford, CA 94305 USA

来源：

NEUROSURGICAL FOCUS | 2019年 / 46卷 / 03期

关键词：

stem cell; spinal cord injury; transplant; trauma; clinical trials; HUMAN ADIPOSE-TISSUE; IN-VITRO DIFFERENTIATION; FUNCTIONAL RECOVERY; BONE-MARROW; NEURAL STEM; NEUROTROPHIC FACTOR; TERATOMA FORMATION; GROWTH-FACTOR; TRANSPLANTATION; BLOOD;

D O I：

10.3171/2018.12.FOCUS18602

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Recent advances in stem cell biology present significant opportunities to advance clinical applications of stem cell-based therapies for spinal cord injury (SCI). In this review, the authors critically analyze the basic science and translational evidence that supports the use of various stem cell sources, including induced pluripotent stem cells, oligodendrocyte precursor cells, and mesenchymal stem cells. They subsequently explore recent advances in stem cell biology and discuss ongoing clinical translation efforts, including combinatorial strategies utilizing scaffolds, biogels, and growth factors to augment stem cell survival, function, and engraftment. Finally, the authors discuss the evolution of stem cell therapies for SCI by providing an overview of completed (n = 18) and ongoing (n = 9) clinical trials.

引用

页数：11

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