Cell-specific gene transfection from a gene-functionalized poly(D,L-lactic acid) substrate fabricated by the layer-by-layer assembly technique

被引：35

作者：

Cai, Kaiyong ^{[1
]}

Hu, Yan ^{[1
]}

Luo, Zhong ^{[1
]}

Kong, Ting ^{[1
]}

Lai, Min ^{[1
]}

Sui, Xiaojing ^{[1
]}

Wang, Yuanliang ^{[1
]}

Yang, Li ^{[1
]}

Deng, Linhong ^{[1
]}

机构：

[1] Chongqing Univ, Coll Bioengn, Chongqing 400044, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 39期

关键词：

cell recognition; DNA; gene transfection; layered materials;

D O I：

10.1002/anie.200800412

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) The surface matters: Along with the degradation of the multilayer structure, galactosylated chitosan/plasmid DNA complexes (see picture) were simultaneously formed in situ for cell uptake and gene transfection. Surface-induced cell-specific recognition and in situ gene transfection were achieved. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7479 / 7481

页数：3

共 19 条

[1] Characterization of chitosan by steric exclusion chromatography [J].

Brugnerotto, J ;

Desbrières, J ;

Roberts, G ;

Rinaudo, M .

POLYMER, 2001, 42 (25) :9921-9927

[2] Build up of multilayered thin films with chitosan/DNA pairs on poly(D,L-lactic acid) films: Physical chemistry and sustained release behavior [J].

Cai, Kaiyong ;

Hu, Yan ;

Wang, Yuanliang ;

Yang, Li .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2008, 84A (02) :516-522

[3] Polysaccharide-protein surface modification of titanium via a layer-by-layer technique: Characterization and cell behaviour aspects [J].

Cai, KY ;

Rechtenbach, A ;

Hao, JY ;

Bossert, J ;

Jandt, KD .

BIOMATERIALS, 2005, 26 (30) :5960-5971

[4] Fuzzy nanoassemblies: Toward layered polymeric multicomposites [J].

Decher, G .

SCIENCE, 1997, 277 (5330) :1232-1237

[5] Electroacoustic miniaturized DNA-biosensor [J].

Gamby, Jean ;

Lazerges, Mathieu ;

Pernelle, Christine ;

Perrot, Hubert ;

Girault, Hubert H. ;

Tribollet, Bernard .

LAB ON A CHIP, 2007, 7 (11) :1607-1609

[6] Third-generation biomedical materials [J].

Hench, LL ;

Polak, JM .

SCIENCE, 2002, 295 (5557) :1014-+

[7] Reversibly erasable nanoporous anti-reflection coatings from polyelectrolyte multilayers [J].

Hiller, J ;

Mendelsohn, JD ;

Rubner, MF .

NATURE MATERIALS, 2002, 1 (01) :59-63

[8] Multiple and time-scheduled in situ DNA delivery mediated by β-cyclodextrin embedded in a polyelectrolyte multilayer [J].

Jessel, N ;

Oulad-Abdeighani, M ;

Meyer, F ;

Lavalle, P ;

Haîkel, Y ;

Schaaf, P ;

Voegel, JC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (23) :8618-8621

[9] Asialoglycoprotein-receptor-targeted hepatocyte imaging using 99mTc galactosylated chitosan [J].

Kim, Eun-Mi ;

Jeong, Hwan-Jeong ;

Kim, Se-Lim ;

Sohn, Myung-Hee ;

Nah, Jae-Woon ;

Bom, Hee-Seung ;

Park, In-Kyu ;

Cho, Chong-Su .

NUCLEAR MEDICINE AND BIOLOGY, 2006, 33 (04) :529-534

[10] Non-viral gene delivery regulated by stiffness of cell adhesion substrates [J].

Kong, HJ ;

Liu, JD ;

Riddle, K ;

Matsumoto, T ;

Leach, K ;

Mooney, DJ .

NATURE MATERIALS, 2005, 4 (06) :460-464

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