Cytokine expression in human labial minor salivary gland epithelial cells in health and disease

被引:24
作者
Fox, PC [1 ]
Brennan, M [1 ]
Di Sun, P [1 ]
机构
[1] NIDR, Clin Invest Sect, Gene Therapy & Therapeut Branch, Bethesda, MD 20892 USA
关键词
minor salivary glands; cytokines; Sjogren's syndrome;
D O I
10.1016/S0003-9969(99)00050-3
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Microdissection of biopsy material from labial minor salivary glands followed by RT-PCR demonstrates extensive production of cytokines IL-2, IL-6, IL-10, TNF-alpha, TGF-beta, and IFN-gamma in both normal glands and in glands affected by Sjogren's syndrome. Continuation of these studies should expand our knowledge of normal salivary gland function and the pathogenis of Sjogren'syndrome.
引用
收藏
页码:S49 / S52
页数:4
相关论文
共 16 条
[1]   New therapeutic avenues in autoimmunity [J].
Amital, H ;
Swissa, M ;
BarDayan, Y ;
Buskila, D ;
Shoenfeld, Y .
RESEARCH IN IMMUNOLOGY, 1996, 147 (06) :361-376
[2]   SJOGRENS-SYNDROME - ORAL AND DENTAL CONSIDERATIONS [J].
ATKINSON, JC ;
FOX, PC .
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION, 1993, 124 (03) :74-&
[3]   Cytokines in autoimmunity [J].
Brennan, FM ;
Feldmann, M .
CURRENT OPINION IN IMMUNOLOGY, 1996, 8 (06) :872-877
[4]   CYTOKINE AND ADHESION MOLECULE EXPRESSION IN THE MINOR SALIVARY-GLANDS OF PATIENTS WITH SJOGRENS-SYNDROME AND CHRONIC SIALOADENITIS [J].
CAULI, A ;
YANNI, G ;
PITZALIS, C ;
CHALLACOMBE, S ;
PANAYI, GS .
ANNALS OF THE RHEUMATIC DISEASES, 1995, 54 (03) :209-215
[5]   LABIAL SALIVARY-GLAND BIOPSY IN SJOGRENS SYNDROME - ASSESSMENT AS A DIAGNOSTIC CRITERION IN 362 SUSPECTED CASES [J].
DANIELS, TE .
ARTHRITIS AND RHEUMATISM, 1984, 27 (02) :147-156
[6]  
EMMERTBUCK MR, 1994, AM J PATHOL, V145, P1285
[7]   Current concepts of autoimmune exocrinopathy - Immunologic mechanisms in the salivary pathology of Sjogren's syndrome [J].
Fox, PC ;
Speight, PM .
CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE, 1996, 7 (02) :144-158
[8]  
FOX RI, 1994, J IMMUNOL, V152, P5532
[9]  
Grisius MM, 1997, J RHEUMATOL, V24, P1089
[10]   CYTOKINE EXPRESSION IN LABIAL SALIVARY-GLANDS FROM PATIENTS WITH PRIMARY SJOGRENS-SYNDROME [J].
OXHOLM, P ;
DANIELS, TE ;
BENDTZEN, K .
AUTOIMMUNITY, 1992, 12 (03) :185-191