Discovery of exceptionally efficient catalysts for solvent-free enantioselective hetero-Diels-Alder reaction

被引：187

作者：

Long, J ^{[1
]}

Hu, JY ^{[1
]}

Shen, XQ ^{[1
]}

Ji, BM ^{[1
]}

Ding, KL ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 01期

关键词：

D O I：

10.1021/ja0172518

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Combinatorial coordination chemistry strategy combined with high-throughput screening techniques has been successfully applied to engineering practical enantioselective catalysts for asymmetric hetero-Diels-Alder reaction. The reaction of Danishefsky's diene with a variety of aldehydes can be carried out with 0.1-0.005 mol % of H4-BINOL/Ti/H4-BINOL or H4-BINOL/Ti/H8-BINOL catalysts at room temperature under solvent- and MS-free conditions to afford dihydropyrone derivatives with up to quantitative yield and 99.8% ee. Copyright © 2002 American Chemical Society.

引用

页码：10 / 11

页数：2

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