Preparation and evaluation of liposomal formulations of tropicamide for ocular delivery

被引:97
作者
Nagarsenker, MS [1 ]
Londhe, VY
Nadkarni, GD
机构
[1] Bombay Coll Pharm, Dept Pharmaceut, Kalina 400098, Mumbai, India
[2] BARC, Radiat Med Ctr, Parel 400012, Mumbai, India
关键词
liposomes; pupil dilatory effect; gamma-scintigraphy; tropicamide;
D O I
10.1016/S0378-5173(99)00265-3
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Tropicamide, a mydriatic, cycloplegic drug was entrapped in liposomes. Liposomes were investigated by laser counting studies, transmission electron microscopy and differential scanning calorimetry for characterization. The precorneal clearance of liposomes was compared with solution by gamma-scintigraphy in the rabbit. The neutral liposomes failed to-demonstrate significant enhancement in precorneal retention ill comparison with aqueous solution. The potential of liposomes as an ophthalmic drug delivery system was investigated: by comparing pupil dilatory effect of tropicamide by topical instillation, in the rabbit eye, of the solution and various drug-loaded liposomal forms, i.e. neutral liposomes, positively charged liposomes and neutral liposomes dispersed in 0.25% (w/v) polycarbophil gel. The positively charged liposomal formulation and liposomes dispersed in polycarbophil eel were found to be more effective than neutral liposomal dispersion when data were statistically treated at the 5% level of significance. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:63 / 71
页数:9
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