The inhibitory effect of a polysaccharide from Codonopsis pilosula on tumor growth and metastasis in vitro

被引：151

作者：

Xin, Tao ^{[1
]}

Zhang, Fubin ^{[2
]}

Jiang, Qiuying ^{[1
]}

Chen, Chunhong ^{[1
]}

Huang, Dayong ^{[1
]}

Li, Yanju ^{[1
]}

Shen, Weixi ^{[1
]}

Jin, Yinghua ^{[1
]}

Sui, Guangjie ^{[2
]}

机构：

[1] Harbin Med Univ, Dept Med Oncol, Affiliated Hosp 2, Harbin 150081, Peoples R China

[2] Harbin Med Univ, Dept Gynecol, Affiliated Tumor Hosp 3, Harbin 150040, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2012年 / 51卷 / 05期

关键词：

Codonopsis pilosula; Polysaccharide; Antitumor; Metastasis; Ovarian cancer; WATER-SOLUBLE POLYSACCHARIDE; CELL-ADHESION; STRUCTURAL-CHARACTERIZATION; CD44; EXPRESSION; MELANOMA; ANTIOXIDANT; LYMPHOCYTES; STRESS; CANCER;

D O I：

10.1016/j.ijbiomac.2012.07.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

In this study, we prepared an acidic polysaccharide (CPPA) from the roots of Codonopsis pilosula. The effects of CPPA on tumor cell growth, invasion, and migration were examined in vitro. The CPPA not only induced a potent inhibitory effect on the invasion and migration potential of human epithelial ovarian cancer HO-8910 cells in vitro, evaluated by wound healing, transwell and cell adhesion assays, but also had an efficient anti-proliferation effect on tumor cells. Moreover, the CD44 expression on the HO-8910 cells was also attenuated by CPPA treatment. Therefore, our results indicate that CPPA may be a potential candidate compound for the prevention of tumor metastasis, presumably by inhibiting invasion, migration and adhesion of tumor cells, as well as the CD44 expression on the tumor cells. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：788 / 793

页数：6

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