Regional specific changes of cerebral metabolism in systemic lupus erythematosus identified by positron emission tomography

被引:7
作者
de Jong, BM
Pruim, J
Sinnige, LGF
Beintema, KD
Spronk, PE
Bootsma, H
Kallenberg, CGM
van Zomeren, AH
Haaxma-Reiche, H
机构
[1] Univ Groningen Hosp, Dept Neurol, NL-9700 RB Groningen, Netherlands
[2] Univ Groningen Hosp, PET Ctr, Groningen, Netherlands
[3] Univ Groningen Hosp, Dept Internal Med, Groningen, Netherlands
关键词
systemic lupus erythematosus (SLE); positron emission tomography (PET); metabolism; basal ganglia;
D O I
10.1159/000008049
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
In order to test the hypothesis whether the pathogenesis of cerebral systemic lupus erythematosus (SLE) may include an immune-mediated deficit in specific vulnerable brain regions, the regional cerebral metabolism in 9 patients with diffuse as well as focal cerebral symptoms was compared with that of 10 age-matched control subjects, The cerebral distribution of 2-[F-18]fluoro-2-deoxy-D- glucose (FDG) uptake was measured by means of positron emission tomography. Subsequently performed statistical parametric mapping showed (i) a relative increase in metabolism in the striatum and (ii) regional decreases in the premotor cortex as a common feature in the patient group. Region of interest measurements of absolute FDG uptake confirmed these findings, The increased striatal activity may support the presence of a direct immune response against neuronal tissue in SLE, similar to the cross-reaction against inhibitory components in striatal tissue provoked by streptococcal antigens.
引用
收藏
页码:187 / 193
页数:7
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