Marginal Structural Models for the Estimation of Direct and Indirect Effects

被引：395

作者：

VanderWeele, Tyler J. ^{[1
]}

机构：

[1] Univ Chicago, Dept Hlth Studies, Chicago, IL 60637 USA

来源：

EPIDEMIOLOGY | 2009年 / 20卷 / 01期

关键词：

CAUSAL INFERENCE; PRINCIPAL STRATIFICATION; SURVIVAL;

D O I：

10.1097/EDE.0b013e31818f69ce

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The estimation of controlled direct effects can be carried out by fitting a marginal structural model and using inverse probability of treatment weighting. To use marginal structural models to estimate natural direct and indirect effects, 2 marginal structural models can be used: I for the effects of the treatment and mediator on the outcome and I for the effect of the treatment on the mediator. Unlike marginal structural models typically used in epidemiologic research, the marginal structural models used to estimate natural direct and indirect effects are made conditional on the covariates.

引用

页码：18 / 26

页数：9

共 37 条

[1]

[Anonymous], SOCIOLOGICAL METHODO

[2] THE MODERATOR MEDIATOR VARIABLE DISTINCTION IN SOCIAL PSYCHOLOGICAL-RESEARCH - CONCEPTUAL, STRATEGIC, AND STATISTICAL CONSIDERATIONS [J].

BARON, RM ;

KENNY, DA .

JOURNAL OF PERSONALITY AND SOCIAL PSYCHOLOGY, 1986, 51 (06) :1173-1182

[3] Sensitivity analyses for unmeasured confounding assuming a marginal structural model for repeated measures [J].

Brumback, BA ;

Hernán, MA ;

Haneuse, SJPA ;

Robins, JM .

STATISTICS IN MEDICINE, 2004, 23 (05) :749-767

[4] Fallibility in estimating direct effects [J].

Cole, SR ;

Hernán, MA .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2002, 31 (01) :163-165

[5]

Didelez V., 2006, Proceedings of the Twenty-Second Conference on Uncertainty in Artificial Intelligence, P138

[6] Principal stratification in causal inference [J].

Frangakis, CE ;

Rubin, DB .

BIOMETRICS, 2002, 58 (01) :21-29

[7] Identifying direct and indirect effects in a non-counterfactual framework [J].

Geneletti, Sara .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 2007, 69 :199-215

[8] Structural accelerated failure time models for survival analysis in studies with time-varying treatments [J].

Hernán, MA ;

Cole, SR ;

Margolick, J ;

Cohen, M ;

Robins, JM .

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2005, 14 (07) :477-491

[9] A definition of causal effect for epidemiological research [J].

Hernán, MA .

JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 2004, 58 (04) :265-271

[10] Estimating the causal effect of zidovudine on CD4 count with a marginal structural model for repeated measures [J].

Hernán, MA ;

Brumback, BA ;

Robins, JM .

STATISTICS IN MEDICINE, 2002, 21 (12) :1689-1709

← 1 2 3 4 →