Age-dependent association between butyrylcholinesterase K-variant and Alzheimer disease-related neuropathology in human brains

被引：19

作者：

Ghebremedhin, E

Thal, DR

Schultz, C

Braak, H

机构：

[1] Univ Frankfurt, Dept Clin Neuroanat, D-60590 Frankfurt, Germany

[2] Univ Bonn, Med Ctr, Inst Neuropathol, D-53105 Bonn, Germany

来源：

NEUROSCIENCE LETTERS | 2002年 / 320卷 / 1-2期

关键词：

Alzheimer disease; Alzheimer disease neuropathology; butyrylcholinesterase; K-variant; apolipoprotein E; genetic association;

D O I：

10.1016/S0304-3940(02)00014-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The association between the K-variant of the butyrylcholinesterase gene (BCHE-K) and Alzheimer disease (AD) or AD-related neuropathology has been reported to date with conflicting results. Here, we determined in a sample of 521 cases the severity of AD-related neuropathology and the polymorphisms of both BCHE-K and apolipoprotein E (ApoE). Histopathologically, all brains were classified according to procedures permitting differentiation of the evolutionary stages of neurofibrillary tangles (NFTs) and amyloid-beta-protein deposition (Abeta-deposits). The results show that the association between BCHE-K and AD-related neuropathology only was limited to homozygotes for the K allele (P = 0.036 for NFTs, and P = 0.045 for Abeta-deposits) at ages greater than or equal to70years but not 50-69 years. Furthermore, no interaction was apparent between BCHE-K and ApoE. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

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页码：25 / 28

页数：4

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